Evaluation of association of vitamin D level with types of proximal femoral fractures in elderly patients
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20184392Keywords:
Proximal femoral fractures, Vitamin D, Elderly, Fracture neck of femur, OsteoporosisAbstract
Background: Proximal femoral fractures are very common in elderly patients. These fractures are thought to be associated with osteoporosis. Vitamin D is a possible risk factor for osteoporosis. So, this study was done to evaluate the association of serum vitamin D level with types of femoral fractures in elderly patients.
Methods: The study was done between September 2013 to August 2016, 75 patients with age >60 years (male and female both) with proximal femoral fractures were studied. Serum 25-hydroxy vitamin D, calcium, phosphate, alkaline phosphatase levels, liver function test, renal function test, hemoglobin and complete blood counts of all the patients were assessed.
Results: On assessment of serum vitamin D in proximal femoral fracture in elderly patients, it shows an increase incidence of proximal femoral fractures in patients with low serum vitamin D level. Fracture of neck of femur was most common among all. Type of fracture has no significant statistical relationship with serum vitamin D levels.
Conclusions: Osteoporosis and serum vitamin D level depends on age and sex of the patient. But type of proximal femoral osteoporotic fracture has no association with either grade of osteoporosis or serum vitamin D level.
Metrics
References
Kanis JA, Odén A, McCloskey EV, Johansson H, Wahl DA, Cooper C. IOF Working Group on Epidemiology and Quality of Life. A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int. 2012;23(9):2239–56.
Fernandes RA, Araújo DV, Takemoto MLS, Sauberman MV. Fraturas do fêmur proximal no idoso: estudo de custo da doença sob a perspectiva de um hospital público no Rio de Janeiro, Brasil. Physis. 2011;21(2):395-416.
Ricci G, Longaray MP, Gonçalves RZ, Ungaretti Neto AS, Manente M, Barbosa LBH. Avaliação da taxa de mortalidade em um ano após fratura do quadril e fatores relacionados à diminuição da sobrevida no idoso. Rev Bras Ortop. 2012;47(3):304-9.
Cooper C, Campion G, Melton LJ., 3rd Hip fractures in the elderly: A world-wide projection. Osteoporos Int. 1992;2:285–9.
MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76:1536-8.
Goswami R, Gupta N, Gosami D, Marwaha RK, Tandon N, Kochupillai N. Prevalence and significance of low 25-hydroxyvitamin D concentration in healthy subjects in Delhi. AMJ Clin Nutr. 2000;72(2):472-5.
Holick MF. McCollum award lecture 1994. Vitamin D: new horizons for the 21st century. Am J Clin Nutr. 1994;60:619-30.
Holick MF. Environmental factors that influence the cutaneous production of vitamin D. AmJ Clin Nutr. 1995;61(Suppl 3):638S-645S.
Ramalho AC, Lazaretti-Castro1 M, Hauache O, Kasamatsu T, Brandão C, Reis AF, et al. Brazilian Fractures of the proximal femur- correlation with Vitamin D Receptor gene polymorphism. J Med Biological Res. 1998;31(7):921-7.
Bartonícek J, Dzupa V, Fric V, Pacovský V, Skála-Rosenbaum J, Svatos F. Epidemiology and economic implication of fractures of proximal femur, proximal humerus, distal radius and fracture dislocation of ankle. 2008;87(4):213-9.
Ensrud KE, Taylor BC, Paudel ML, Cauley JA, Cawthon PM, Cummings SR, et al. Serum 25-hydroxyvitamin D levels and rate of hip bone losing older men. J Clin Endocrinol Metab. 2009;94(8):2773-80.
Isaia G, Giorgino R, Rini GB, Bevilacqua M, Maugeri D, Adami S. Prevalence of hypovitaminosis D in elderly women in Italy: clinical consequences and risk factors. Osteoporos Int. 2003;14:577-82.
Harinarayan CV, Joshi SR. Vitamin D status in india-It’s implications and remedial measures. J Assoc Physicians India. 2009;57:40-8.
Bruce DG, St John A, Nicklason F, Goldswain PR. Secondary hyperparathyroidism in patients from Western Australia with hip fracture: Relationship to type of hip fracture, renal function and vitamin D deficiency. J Am Geriatr Soc. 1999;47:354-9.
Fisher A, Srikusalanukul W, Davis M, Smith P. Hip fracture type: Important role of parathyroid hormone (PTH) response to hypovitaminosis D. Bone. 2010;47(2):400-7.