Evaluation of association of vitamin D level with types of proximal femoral fractures in elderly patients

Authors

  • Afroz Ahmed Khan Department of Orthopedics, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • Vipin Kumar Department of Orthopedics, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • Ashok Kumar Yadav Department of Orthopedics, B. R. D. Medical College and Nehru Hospital, Gorakhpur, Uttar Pradesh, India
  • Robin Singh Department of Orthopedics, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • Karn Singh Chauhan Department of Orthopedics, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
  • Areeba Hasan Department of Community Medicine, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20184392

Keywords:

Proximal femoral fractures, Vitamin D, Elderly, Fracture neck of femur, Osteoporosis

Abstract

Background: Proximal femoral fractures are very common in elderly patients. These fractures are thought to be associated with osteoporosis. Vitamin D is a possible risk factor for osteoporosis. So, this study was done to evaluate the association of serum vitamin D level with types of femoral fractures in elderly patients.

Methods: The study was done between September 2013 to August 2016, 75 patients with age >60 years (male and female both) with proximal femoral fractures were studied. Serum 25-hydroxy vitamin D, calcium, phosphate, alkaline phosphatase levels, liver function test, renal function test, hemoglobin and complete blood counts of all the patients were assessed.

Results: On assessment of serum vitamin D in proximal femoral fracture in elderly patients, it shows an increase incidence of proximal femoral fractures in patients with low serum vitamin D level. Fracture of neck of femur was most common among all. Type of fracture has no significant statistical relationship with serum vitamin D levels.

Conclusions: Osteoporosis and serum vitamin D level depends on age and sex of the patient. But type of proximal femoral osteoporotic fracture has no association with either grade of osteoporosis or serum vitamin D level.

Author Biography

Afroz Ahmed Khan, Department of Orthopedics, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India

Assistant professor Department of Orthopedics, Era’s Lucknow Medical College, Lucknow

References

Kanis JA, Odén A, McCloskey EV, Johansson H, Wahl DA, Cooper C. IOF Working Group on Epidemiology and Quality of Life. A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int. 2012;23(9):2239–56.

Fernandes RA, Araújo DV, Takemoto MLS, Sauberman MV. Fraturas do fêmur proximal no idoso: estudo de custo da doença sob a perspectiva de um hospital público no Rio de Janeiro, Brasil. Physis. 2011;21(2):395-416.

Ricci G, Longaray MP, Gonçalves RZ, Ungaretti Neto AS, Manente M, Barbosa LBH. Avaliação da taxa de mortalidade em um ano após fratura do quadril e fatores relacionados à diminuição da sobrevida no idoso. Rev Bras Ortop. 2012;47(3):304-9.

Cooper C, Campion G, Melton LJ., 3rd Hip fractures in the elderly: A world-wide projection. Osteoporos Int. 1992;2:285–9.

MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76:1536-8.

Goswami R, Gupta N, Gosami D, Marwaha RK, Tandon N, Kochupillai N. Prevalence and significance of low 25-hydroxyvitamin D concentration in healthy subjects in Delhi. AMJ Clin Nutr. 2000;72(2):472-5.

Holick MF. McCollum award lecture 1994. Vitamin D: new horizons for the 21st century. Am J Clin Nutr. 1994;60:619-30.

Holick MF. Environmental factors that influence the cutaneous production of vitamin D. AmJ Clin Nutr. 1995;61(Suppl 3):638S-645S.

Ramalho AC, Lazaretti-Castro1 M, Hauache O, Kasamatsu T, Brandão C, Reis AF, et al. Brazilian Fractures of the proximal femur- correlation with Vitamin D Receptor gene polymorphism. J Med Biological Res. 1998;31(7):921-7.

Bartonícek J, Dzupa V, Fric V, Pacovský V, Skála-Rosenbaum J, Svatos F. Epidemiology and economic implication of fractures of proximal femur, proximal humerus, distal radius and fracture dislocation of ankle. 2008;87(4):213-9.

Ensrud KE, Taylor BC, Paudel ML, Cauley JA, Cawthon PM, Cummings SR, et al. Serum 25-hydroxyvitamin D levels and rate of hip bone losing older men. J Clin Endocrinol Metab. 2009;94(8):2773-80.

Isaia G, Giorgino R, Rini GB, Bevilacqua M, Maugeri D, Adami S. Prevalence of hypovitaminosis D in elderly women in Italy: clinical consequences and risk factors. Osteoporos Int. 2003;14:577-82.

Harinarayan CV, Joshi SR. Vitamin D status in india-It’s implications and remedial measures. J Assoc Physicians India. 2009;57:40-8.

Bruce DG, St John A, Nicklason F, Goldswain PR. Secondary hyperparathyroidism in patients from Western Australia with hip fracture: Relationship to type of hip fracture, renal function and vitamin D deficiency. J Am Geriatr Soc. 1999;47:354-9.

Fisher A, Srikusalanukul W, Davis M, Smith P. Hip fracture type: Important role of parathyroid hormone (PTH) response to hypovitaminosis D. Bone. 2010;47(2):400-7.

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Published

2018-10-24

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Original Research Articles