Management strategies for osteoporotic vertebral compression fractures: a prospective multicentric study
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20262326Keywords:
Osteoporosis, Vertebral compression fracture, Vertebroplasty, Kyphoplasty, Prospective studyAbstract
Background: Osteoporotic vertebral compression fractures (OVCFs) are a major cause of morbidity among the elderly population, leading to pain, reduced mobility, and diminished quality of life. Various management strategies exist, including conservative treatment, vertebroplasty, and kyphoplasty; however, optimal treatment remains controversial.
Methods: A prospective observational study was conducted across three tertiary care centres in Odisha, India, from December 2023 to December 2025. A total of 220 patients diagnosed with OVCFs were enrolled. Patients were categorized into three groups: conservative management (Group A), vertebroplasty (Group B), and kyphoplasty (Group C). Outcomes were assessed using Visual analog scale (VAS), Oswestry disability index (ODI), and radiological parameters at baseline, 3 months, 6 months, and 12 months.
Results: Significant improvement in pain and functional outcomes was observed in all groups (p<0.001). Kyphoplasty demonstrated superior pain relief and vertebral height restoration compared to other modalities (p<0.05). Vertebroplasty showed faster early pain relief compared to conservative treatment.
Conclusions: Kyphoplasty offers better long-term outcomes in OVCFs, while vertebroplasty provides rapid pain relief. Conservative treatment remains suitable for mild cases.
References
Kanis JA. Diagnosis of osteoporosis. Lancet. 2002;359(9321):1929-36.
Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2005;16(S2):S3-7.
Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. Arch Osteoporos. 2013;8(2):136.
Silverman SL. The clinical consequences of vertebral compression fracture. J Bone Miner Res. 1992;7(5):1187-91.
Old JL, Calvert M. Vertebral compression fractures in the elderly. Am Fam Physician. 2004;69(1):111-6.
Klazen CAH, Lohle PNM, De Vries J, Jansen FH, Tielbeek AV, Blonk MC, et al. Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet. 2010;376(9746):1085-92.
Galibert P, Deramond H, Rosat P, Le Gars D. Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie. 1987;33(2):166-8.
Lieberman IH, Dudeney S, Reinhardt MK, Bell G. Initial outcome and efficacy of kyphoplasty in the treatment of painful osteoporotic vertebral compression fractures. Spine (Phila Pa 1976). 2001;26(14):1631-8.
Buchbinder R, Osborne RH, Ebeling PR, Wark JD, Mitchell P, Wriedt C, et al. A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med. 2009;361(6):557-68.
Cauley JA. Public health impact of osteoporosis. J Gerontol A Biol Sci Med Sci. 2013;68(10):1243-51.
Kallmes DF, Comstock BA, Heagerty PJ, Turner JA, Wilson DJ, Diamond TH, et al. A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med. 2009;361(6):569-79.
McGraw JK, Cardella J, Barr JD, Mathis JM, Sanchez O, Schwartzberg MS, et al. Society of Interventional Radiology quality improvement guidelines for percutaneous vertebroplasty. Radiology. 2003;226(2):366-72.
Voormolen MHJ, Mali WPTM, Lohle PNM, Fransen H, Lampmann LEH, Van der Graaf Y, et al. Percutaneous vertebroplasty compared with optimal pain medication treatment for patients with acute osteoporotic vertebral compression fractures: short-term clinical outcome of the VERTOS study. AJNR Am J Neuroradiol. 2007;28(3):555-60.
Wardlaw D, Cummings SR, Van Meirhaeghe J, Bastian L, Tillman JB, Ranstam J, et al. Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. Lancet. 2009;373(9668):1016-24.
Berenson J, Pflugmacher R, Jarzem P, Zonder J, Schechtman K, Tillman JB, et al. Balloon kyphoplasty versus non-surgical care for cancer-related vertebral compression fractures: a multicentre, randomised controlled trial. Lancet Oncol. 2011;12(3):225-35.
Chen AT, Cohen DB, Skolasky RL. Impact of nonoperative treatment, vertebroplasty, and kyphoplasty. Spine J. 2014;14(10):2497-503.
Taylor RS, Fritzell P, Taylor RJ. Balloon kyphoplasty in the management of vertebral compression fractures. Spine. 2007;32(24):2849-55.