Consanguinity and family history as risk factors for developmental dysplasia of the hip in Omani children
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20262018Keywords:
Developmental dysplasia of the hip, Consanguinity, Genetic predisposition, Pediatric orthopedicsAbstract
Background: Developmental dysplasia of the hip (DDH) is a multifactorial disorder influenced by genetic and environmental factors, with variation in risk profiles across populations, particularly in regions with high consanguinity rates. This study aimed to evaluate risk factors associated with DDH among Omani children.
Methods: This retrospective hospital-based case-control study included children born at Khoula Hospital between 2009 and 2019. Of 567 screened children, 100 confirmed DDH cases were included. A control group of 200 children was matched for age and sex. Univariable and multivariable logistic regression analyses were performed.
Results: Family history (OR 4.38, 95% CI 1.81–10.55; p=0.001) and consanguinity (OR 2.02, 95% CI 1.19–3.46; p=0.010) were independent predictors of DDH. Other factors were not statistically significant.
Conclusions: Family history and consanguinity are significant independent risk factors for DDH in this population, supporting targeted screening strategies.
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References
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