Efficacy of autologous platelet-rich plasma versus corticosteroid injections in degenerative facet joint syndrome
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20261217Keywords:
Degenerative facet joint syndrome, Platelet-rich plasma, Corticosteroid, Intra-articular injection, Low back painAbstract
Background: Degenerative Facet Joint Syndrome (DFJS) is a common cause of chronic low back pain, particularly in the elderly. Current treatments, including intra-articular corticosteroid (CS) injections, offer short-term relief but are associated with adverse effects. Autologous platelet-rich plasma (PRP) injections have emerged as a potential alternative due to their regenerative properties and minimal side effects. This study compares the efficacy of single intra-articular PRP versus CS injections in managing DFJS. To evaluate and compare the short- and long-term functional outcomes of intra-articular PRP and CS injections in patients with DFJS.
Methods: This prospective, randomized controlled trial included 74 patients diagnosed with DFJS, randomly divided into two groups. Group A (n=37) received a single intra-articular PRP injection, while Group B (n=37) received a single intra-articular CS injection. Outcomes were assessed using the Visual Analog Scale, Present Pain Index, Modified Oswestry Disability Index, Roland-Morris Questionnaire, and Short Form Health-12 at 4 weeks, 8 weeks, 12 weeks, 6 months, and 1-year post-injection.
Results: Both groups showed significant reductions in pain and disability scores. In the short term, the CS group demonstrated greater improvement, though not statistically significant. However, at 1 year, the PRP group showed superior outcomes in pain reduction, functional ability, and quality of life, with long-term benefits surpassing those of CS.
Conclusions: Intra-articular PRP injections offer a safe and effective treatment option for DFJS, providing longer-lasting relief compared to CS. While both treatments are beneficial, PRP may be the preferable choice for patients seeking sustained improvement in pain and functionality.
References
Kotb SY, Sherif NM, Saleh HA, Ahmed SF, Sakr HM, Taeimah MO. The role of intra-articular injection of autologous platelet-rich plasma versus corticosteroids in the treatment of synovitis in lumbar facet joint disease. Saudi Med J. 2022;43(11):1200-8.
Won HS, Yang M, Kim YD. Facet joint injections for management of low back pain: a clinically focused review. Anesth Pain Med. 2020;15(1):8-18.
Mann SJ, Viswanath O, Singh P. Lumbar Facet Arthropathy. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2023. Available at: http://www.ncbi.nlm.nih.gov/books/NBK538228/. Accessed on 17 December 2025.
Su DCJ, Chang KV. Facet Arthritis. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2024. Available at: http://www. ncbi.nlm.nih.gov/books/NBK493233/. Accessed on 17 December 2025.
Monfett M, Harrison J, Boachie-Adjei K, Lutz G. Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update. Int Orthop. 2016;40(6):1321-8.
Chang RG, Hurwitz NR, Harrison JR, C J, Lutz GE. Ankylosing Spondylitis Versus Internal Disc Disruption: A Case Report Treated Successfully with Intradiscal Platelet-Rich Plasma Injection. Spine Res. 2017;3(1).
Mohammed S, Yu J. Platelet-rich plasma injections: an emerging therapy for chronic discogenic low back pain. J Spine Surg. 2018;4(1):115-22.
Filardo G, Previtali D, Napoli F, Candrian C, Zaffagnini S, Grassi A. PRP Injections for the Treatment of Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials. Cartilage. 2021;13(1):364S-75.
IBM SPSS Statistics for Windows, Version 23.0. Armonk, NY: IBM Corp. 2015. Available at: https://www.ibm.com/products/spss-statistics?. Accessed on 17 December 2025.
Wu J, Du Z, Lv Y, Zhang J, Xiong W, Wang R, et al. A New Technique for the Treatment of Lumbar Facet Joint Syndrome Using Intra-articular Injection with Autologous Platelet Rich Plasma. Pain Physician. 2016;19(8):617-25.
Singh C, Yadav S, Loha S, Prakash S, Paswan AK. Comparison of intra-articular lumbar facet joint injection of platelet-rich plasma and steroid in the treatment of chronic low back pain: A prospective study. J Orthop Trauma Rehabil. 2023.
Navani A, Ambach M, Calodney A, Rosenthal R, Li G, Mahoney CB, et al. The Safety and Effectiveness of Orthobiologic Injections for Discogenic Chronic Low Back Pain: A Multicenter Prospective, Crossover, Randomized Controlled Trial with 12 Months Follow-up. Pain Physician. 2024;27(1):E65-77.
Monfett M, Harrison J, Boachie-Adjei K, Lutz G. Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update. Int Orthop. 2016;40(6):1321-8.
Patel A, Koushik S, Schwartz R, Gritsenko K, Farah F, Urits I, et al. Platelet-Rich Plasma in the Treatment of Facet Mediated Low Back Pain: A Comprehensive Review. Orthop Rev (Pavia). 2022;14(4):37076.
Hellmich D, Kob A, Deubler R, Schröder C, Rose P, Elsäßer R. Acute Treatment of Facet Syndrome by CT-Guided Injection of Dexamethasone-21-Palmitate Alone and in Combination with Mepivacaine. Clin Drug Investig. 2004;24(10):559-67.
Kawabata S, Akeda K, Yamada J, Takegami N, Fujiwara T, Fujita N, et al. Advances in Platelet-Rich Plasma Treatment for Spinal Diseases: A Systematic Review. Int J Mol Sci. 2023;24(8):7677.
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