Vertebral artery safe zone in anterior odontoid screw fixation

Authors

  • Rashmi Malhotra epartment of Anatomy, AIIMS, Rishikesh, Uttarakhand, India
  • Bharti Devi Department of Anatomy, SGT University, Gurugram, Haryana, India
  • Urvi Sharma epartment of Anatomy, AIIMS, Rishikesh, Uttarakhand, India
  • Rajnish Arora Department of Neurosurgery, AIIMS, Rishikesh, Uttarakhand, India
  • Pankaj Kandwal Department of Orthopaedics, AIIMS, Rishikesh, Uttarakhand, India
  • Mukesh Singla epartment of Anatomy, AIIMS, Rishikesh, Uttarakhand, India

DOI:

https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20260509

Keywords:

Vertebral artery, Odontoid process, Anterior odontoid screw fixation, C2 vertebra, Safe surgical zone, Inter-vertebral artery distance

Abstract

Background: Anterior odontoid screw fixation is a surgical technique for management of Type II odontoid fractures. The vertebral artery (VA) is located near odontoid process, making it more susceptible to injury during screw fixation. So, present study aimed to determine anatomical safe zone, which improves accuracy in screw fixation and enhances operative outcomes.

Methods: This observational study was conducted in the Department of Anatomy at All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India. Total of 10 formalin-fixed cadaver necks were dissected. Inter-VA distances were measured from midline C2 to left and right sides of VA loops. Each measurement was repeated independently, and CT angiographic data were also analysed for comparison with cadaveric findings.

Results: Inter-VA distance in cadavers ranged from 28 mm to 36.1 mm, with a mean of 32.95±2.72 mm. The mean distance from the C2 midline to right VA loop was 15.61±1.25 mm, while left measured 17.24±1.80 mm, indicating a relatively wider zone on left side. CT angiographic measurements demonstrated narrower inter-VA distances (mean 25.3±3.29 mm), significant anatomical variability and differences between in-vivo and cadaveric assessments.

Conclusions: An accurate understanding of inter VA distance at the C2 level is critical for safe anterior cervical surgical approaches. Understanding these morphometric variations enables surgeons to anticipate high-risk areas and determine the optimal screw trajectory and size. As a result, pre-operative CT Angiography examination of the VA path is critical for reducing problems and ensuring optimal surgical outcomes at C2 level.

Metrics

Metrics Loading ...

References

Anderson LD, D’Alonzo RT. Fractures of the odontoid process of the axis. J Bone Joint Surg Am. 1974;56:1663-74. DOI: https://doi.org/10.2106/00004623-197456080-00017

Watanabe M. Radiological assessment of vertebral artery proximity to the dens. Spine. 1997;22:2149-54.

Cacciola F, Phalke U, Goel A. Vertebral artery anomalies at the craniovertebral junction: A CT angiographic study. Spine. 2004;29:1965-70.

Gupta S, Goel A. Quantitative anatomy of vertebral artery in Indian population. Neurol India. 2000;48:324-9.

Böhler J. Anterior stabilization for acute fractures and nonunions of the dens. J Bone Joint Surg Am. 1982;64:18-27. DOI: https://doi.org/10.2106/00004623-198264010-00004

Apfelbaum RI, Lonser RR, Veres R, Casey A. Direct anterior screw fixation for recent and remote odontoid fractures. J Neurosurg. 2000;93:227-36. DOI: https://doi.org/10.3171/spi.2000.93.2.0227

Seybold EA, Bayley JC. Functional outcome of surgically and conservatively managed dens fractures. Spine. 1998;23:1837-45. DOI: https://doi.org/10.1097/00007632-199809010-00006

Smith HE, Kerr SM, Fehlings MG. Trends in management of odontoid fractures in the elderly. Spine. 2013;38:1146-51.

Hasegawa K. Morphometric analysis of the axis for surgical considerations. Spine. 1991;16593-6.

Paramore CG, Dickman CA, Sonntag VK. The anatomical suitability of the anterior C1-C2 transarticular screw fixation. J Neurosurg. 1996;85:221-4. DOI: https://doi.org/10.3171/jns.1996.85.2.0221

Devin CJ, Kang JD: Vertebral artery injuries in cervical spine surgery. Instr Course Lect. 2009;58:717-28.

Smith MD, Emery SE, Dudley A, Murray KJ, Leventhal M. Vertebral artery injury during anterior decompression of the cervical spine. J Bone Joint Surg Br 1993;75:410-5. DOI: https://doi.org/10.1302/0301-620X.75B3.8496209

Lu J, Ebraheim NA, Georgiadis GM, Yang H, Yeasting RA. Anatomic considerations of the vertebral artery: implications for anterior decompression of the cervical spine. J Spinal Disorders 1998;11(3):233-6. DOI: https://doi.org/10.1097/00002517-199806000-00010

Verbiest H. The lateral approach to the cervical spine. Clin Neurosurg. 1973;20:295-305. DOI: https://doi.org/10.1093/neurosurgery/20.CN_suppl_1.295

Macdonald RL, Fehlings MG, Tator CH, Lozano A, Fleming JR, Gentili F, et al. Multilevel anterior cervical corpectomy and fibular allograft fusion for cervical myelopathy. J Neurosurg. 1997;86:990-7. DOI: https://doi.org/10.3171/jns.1997.86.6.0990

Golfinos JG, Dickman CA, Zabramski JM, Sonntag VKH, Spetzler RF. Repair of vertebral artery injury during anterior cervical decompression. Spine. 1994;19(22):25526. DOI: https://doi.org/10.1097/00007632-199411001-00010

Güvençer M, Men S, Naderi S, Kiray A, Tetik S. The V2 segment of the vertebral artery in anterior and anterolateral cervical spinal surgery: a cadaver angiographic study. Clin Neurol Neurosurg. 2006;108(5):440-5. DOI: https://doi.org/10.1016/j.clineuro.2005.04.006

Cruz-Elizondo MA, Villarreal-Silva EE, Quiroga-Garza A: Safety ranges in v3 segment of the vertebral artery for surgical procedures at the craniocervical junction. Int J Morphol. 2020;38:140-6. DOI: https://doi.org/10.4067/S0717-95022020000100140

Güvenç Y, Verimli U, Bıyıklı E, Topal T, Ziyal I. Evaluation of the Distance of the V3 Segments of the Vertebral Artery to the C1 Lateral Mass and C2 Pedicle on the Dominant and Nondominant Sides: A Cadaver Study. Clin Experiment Health Sci. 2024;14(4):1003-7. DOI: https://doi.org/10.33808/clinexphealthsci.1431980

Hyung L, Kim JS, Chung EJ, Yi HA, Chung IS, Lee SR, et al. Infarction in the Territory of Anterior Inferior Cerebellar Artery: Spectrum of Audiovestibular Loss. Stroke. 2009;40:3745-51. DOI: https://doi.org/10.1161/STROKEAHA.109.564682

Dodevski A, Tosovska Lazarova D. Anatomical Features and Clinical Importance of the Vertebral Artery. Maced J Med Sci. 2012;5(3):328-35. DOI: https://doi.org/10.3889/MJMS.1857-5773.2012.0251

Alfaouri MK, Al-Hadidi AM. Morphology of the vertebral artery in Asian population. Asian J Med Sci. 2014;5(4):84-8. DOI: https://doi.org/10.71152/ajms.v5i4.3349

Khanfour AA, El Sekily NM. Relation of the vertebral artery segment from C1 to C2 vertebrae: An anatomical study. Alex J Med. 2015;51(2):143-51. DOI: https://doi.org/10.1016/j.ajme.2014.05.007

Arthur J, Quiroga M, Russo A, Russo V, Graziano F, Velasquez A, et al. Normal anatomical variations of the V3 segment of the vertebral artery: surgical implications. J Neurosurg Spine. 2010;13:451-60. DOI: https://doi.org/10.3171/2010.4.SPINE09824

Gogia T, Dasgupta T, Goel N, Singh N, Rajan A, Das M, et al. Osteological morphometric analysis of instrumentation safe zones of C1 and C2 vertebra in North Indian population: a multicentric study. Int J Res Orthop. 2023;9(6):1148-59. DOI: https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20233154

Yeom JS, Buchowski JM, Kim HJ, Chang BS, Lee CK, Riew KD. Risk of vertebral artery injury: comparison between C1-C2 transarticular and C2 pedicle screws. Spine J. 2013;13:775-85. DOI: https://doi.org/10.1016/j.spinee.2013.04.005

Meyer D, Meyer F, Kretschmer T, Börm W: Translaminar screws of the axis-an alternative technique for rigid screw fixation in upper cervical spine instability. Neurosurg Rev. 2012;35:255-61. DOI: https://doi.org/10.1007/s10143-011-0358-x

Singla M, Kandwal P, Malhotra R, Ansari MS, Arora RK, Bisht K, et al. Surgical anatomy of vertebral artery in relation to atlantoaxial instrumentation: A cadaveric study. Cureus. 2023;15(3):35949. DOI: https://doi.org/10.7759/cureus.35949

Downloads

Published

2026-02-24

How to Cite

Malhotra, R., Devi, B., Sharma, U., Arora, R., Kandwal, P., & Singla, M. (2026). Vertebral artery safe zone in anterior odontoid screw fixation. International Journal of Research in Orthopaedics, 12(2), 416–420. https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20260509

Issue

Section

Original Research Articles