Effectiveness of percutaneous autologous bone marrow injection in delayed and non-union of long bones after definitive fixation
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20253758Keywords:
Percutaneous autologous bone marrow injection, Non-union, Delayed union, Long bones, OsteogenesisAbstract
Background: Delayed and non-union of long bones remain challenging complications despite stable fixation. Percutaneous autologous bone marrow injection (PABMI) provides osteogenic stimulation without the morbidity of open grafting.
Methods: This prospective observational study included 32 patients with delayed or non-union following internal fixation. Forty to sixty milliliters of autologous bone marrow aspirate was collected from the anterior iliac crest and injected percutaneously around the non-union site under fluoroscopic guidance. Patients were followed clinically and radiologically at 4, 8, 16, and 24 weeks.
Results: Radiological union improved progressively, from 3.1% at 4 weeks to 87.5% at 24 weeks (p=0.02). Patients operated within 1 week of injury and those presenting within 12 months of fixation had significantly higher union rates (p=0.021 and p=0.0038). No major complications were observed apart from transient donor-site pain.
Conclusion: PABMI is a safe, simple, and effective biological method for achieving union in delayed and non-union of long bones, with earlier intervention significantly improving outcomes.
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References
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