Deep infection rate in primary total knee arthroplasty: a case series from Oman
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20252654Keywords:
Infection, Laminar flow, Revision, Surgery, Total knee arthroplastyAbstract
The aim of this report is to assess deep infection rate in total knee arthroplasty (TKA), in a clean theatre, but without using laminar flow. This report is a retrospective case series of TKA conducted in the same hospital and same single operating room, by a single surgeon, to assess the percentage of post operative deep infection, that needed surgical intervention between June 2016 and December 2023. Infection rate was compared to the rate reported in the literature. A total of 430 knee replacements were reviewed, with data obtained from the electronic medical record system. All of these cases were performed under strict vigilance to prevent infection, all were given pre operative prophylactic antibiotics, and all had a surgical drain that was removed at the first post operative day. Prosthetic joint infections (PJI) was defined as a TKA that needed further surgical intervention for a clinical picture and investigations suggestive of deep infection. In this report, four patients out of a total of 430 patients (0.93%), who underwent primary TKA had developed PJIs as defined. Patient’s age ranged from 57 to 71 years (mean 66 years), with three females and one male patient. Two patients underwent staged revision TKA after confirmation of PJI, while other two patients underwent debridement, change of insert, and implant retention. This report has concluded a rate of deep infection that is comparable to the reported rate in the literature, despite that no laminar flow was used in this case series. Using a surgical drain did not seem to increase the infection rate. Two of the infected cases were from bacteria that cannot be surgically acquired, making the surgically acquired rate of infection even lower (0.47%).
Metrics
References
Dheerendra S, Khan W, Saeed MZ, Goddard N. Recent developments in total hip replacements: cementation, articulation, minimal-invasion and navigation. J. Perioper. Pract. 2010;20(4):133-8. DOI: https://doi.org/10.1177/175045891002000401
Wong JM, Khan WS, Saksena J. The role of navigation in total knee replacement surgery. J Perioper Pract. 2013;23(9):202-7. DOI: https://doi.org/10.1177/175045891302300905
Kurtz SM, Lau E, Watson H, Schmier JK, Parvizi J. Economic burden of periprosthetic joint infection in the United States. J Arthroplasty. 2012;27:61-5. DOI: https://doi.org/10.1016/j.arth.2012.02.022
Charnley J. A clean-air operating enclosure. Br J Surg. 1964;51:202-5. DOI: https://doi.org/10.1002/bjs.1800510309
Diab-Elschahawi M, Berger J, Blacky A, Kimberger O, Oguz R, Kuelpmann R, et al. Impact of different-sized laminar air flow versus no laminar air flow on bacterial counts in the operating room during orthopedic surgery. Am J Infect Control. 2011;39(7):e25-9. DOI: https://doi.org/10.1016/j.ajic.2010.10.035
Lidwell OM, Elson RA, Lowbury EJ, Whyte W, Blowers R, Stanley SJ, et al. Ultraclean air and antibiotics for pre-vention of post operative infection: a multicentre study of 8,052 joint replacement operations. Acta Orthop Scand. 1987;58(1):4-13. DOI: https://doi.org/10.3109/17453678709146334
Lidwell OM, Lowbury EJ, Whyte W, Blowers R, Stanley SJ, Lowe D. Effect of ultraclean air in operating rooms on deep sepsis in the joint after total hip or knee replacement: a randomised study. Br Med J. 1982;285(6334):10-4. DOI: https://doi.org/10.1136/bmj.285.6334.10
Lindsay W, Bigsby E, Bannister G. Prevention of infection in orthopaedic joint replacement. J Perioper Pract. 2011;21(6):206-9. DOI: https://doi.org/10.1177/175045891102100604
Sloan M, Premkumar A, Sheth NP. Projected Volume of Primary Total Joint Arthroplasty in the U.S. to 2030. J Bone Joint Surg Am. 2014;2018(100):1455-60. DOI: https://doi.org/10.2106/JBJS.17.01617
Ramachandran M, Eastwood D, Singh D, Skinner J. Basic Orthopaedic Sciences; the Stanmore Guide. London: Hodder Arnold. 2007. DOI: https://doi.org/10.1201/b13426
James M, Khan WS, Nannaparaju MR, Bhamra JS, Morgan-Jones R. Current Evidence for the Use of Laminar Flow in Reducing Infection Rates in Total Joint Arthroplasty. Open Orthop J. 2015;9:495-8. DOI: https://doi.org/10.2174/1874325001509010495
Dreghorn CR, Hamblen DL. Revision arthroplasty: a high price to pay. BMJ. 1989;298(6674):648-9. DOI: https://doi.org/10.1136/bmj.298.6674.648
Hooper GJ, Rothwell AG, Frampton C, Wyatt MC. Does the use of laminar flow and space suits reduce early deep infection after total hip and knee replacement? the ten-year results of the New Zealand Joint Registry. J Bone Joint Surg Br. 2011;93(1):85-90. DOI: https://doi.org/10.1302/0301-620X.93B1.24862
Brandt C, Hott U, Sohr D, Daschner F, Gastmeier P, Rüden H. Operating room ventilation with laminar airflow shows no protective effect on the surgical site infection rate in orthopedic and abdominal surgery. Ann Surg. 2008;248(5):695-700. DOI: https://doi.org/10.1097/SLA.0b013e31818b757d
Holton J, Ridgway GL. Commissioning operating theatres. J Hosp Infect. 1993;23(2):153-60. DOI: https://doi.org/10.1016/0195-6701(93)90019-V
Teo BJX, Woo YL, Phua JKS, Chong HC, Yeo W, Tan AHC. Laminar flow does not affect risk of prosthetic joint infection after primary total knee replacement in Asian patients. J Hosp Infect. 2020;104(3):305-8. DOI: https://doi.org/10.1016/j.jhin.2019.12.014
Ouyang X, Wang Q, Li X, Zhang T, Rastogi S. Laminar airflow ventilation systems in orthopaedic operating room do not prevent surgical site infections: a systematic review and meta-analysis. J Orthop Surg Res. 2023;18(1):572. DOI: https://doi.org/10.1186/s13018-023-03992-2
Tai DBG, Patel R, Abdel MP, Berbari EF, Tande AJ. Microbiology of hip and knee periprosthetic joint infections: a database study. Clin Microbiol Infect. 2022;28(2):255-9. DOI: https://doi.org/10.1016/j.cmi.2021.06.006
Hasenauer MD, Ho H, Engh CA 3rd, Engh CA Jr. Factors Associated with the Incidence and Timing of Total Knee Arthroplasty Infection. J Arthroplasty. 2022;37(6S):S276-80. DOI: https://doi.org/10.1016/j.arth.2022.02.034
Weinstein EJ, Stephens-Shields AJ, Newcomb CW, Silibovsky R, Nelson CL, O'Donnell JA, et al. Incidence, Microbiological Studies, and Factors Associated with Prosthetic Joint Infection After Total Knee Arthroplasty. JAMA Netw Open. 2023;6(10):e2340457. DOI: https://doi.org/10.1001/jamanetworkopen.2023.40457
Rosteius T, Jansen O, Fehmer T, Baecker H, Citak M, Schildhauer TA, et al. Evaluating the microbial pattern of periprosthetic joint infections of the hip and knee. J Med Microbiol. 2018;67(11):1608-13. DOI: https://doi.org/10.1099/jmm.0.000835