Study of effect of zoledronic acid on back pain in patients with osteoporosis
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20252632Keywords:
Back pain, Osteoporosis, Zoledronic acidAbstract
Background: The objective of the study was to assess functional result in back pain treated with a Zoledronic acid.
Methods: A prospective observational study was conducted over period of 18 months. SMIMER-Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India. Thirty-eight patients with various stages of back pain treated with zoledronic acid fulfilling selection criteria admitted in department of orthopaedics in tertiary health care hospital in Surat. Follow up was done after 2nd and 6th month and recording of pain relief in term of VAS and MODQ score.
Results: We expected that Patients after receiving Zoledronic acid shows an appreciable and statistically significant improvement in back pain & related complains as well as improvement in monthly follow-up period compared to previous status based on VAS score & MODQ.
Conclusions: Our findings have shown that there is a statistically significant improvement in complain of back pain over period of 6 months as compared to previous status of patient.
Metrics
References
Bayray A, Enquselassie F. The effect of parity on bone mineral density in postmenopausal women: a systematic review. J Osteopor Phys Act. 2013;1:104. DOI: https://doi.org/10.4172/2329-9509.1000104
Aldosh M. Importance of recognition of osteoporosis and the radiologic diagnosis using DEXA technique. J Osteopor Physical Act. 2017;5:206. DOI: https://doi.org/10.4172/2329-9509.1000206
Tu KN, Lie JD, Wan CK. Osteoporosis: a review of treatment options. 2018;43:92-104.
Chitten JJ, James B. Prevalence of osteopenia and osteoporosis in orthopaedic outpatients in Southern India. J Clin Diagn Res. 2018;12:14-7. DOI: https://doi.org/10.7860/JCDR/2018/34109.11269
Hemalata, Reeba MM, Sreekala VK. The prevalence of osteoporosis and osteopenia in persons above 50 years attending a tertiary care hospital in South India. J Med Sci Clin Res. 2016;4:14458-62. DOI: https://doi.org/10.18535/jmscr/v4i12.27
Moroni A. An overview on the approaches to osteoporotic vertebral fractures management. J Osteopor Phys Act. 2014;114. DOI: https://doi.org/10.4172/2329-9509.1000114
Optimizing sequential and combined anabolic and antiresorptive osteoporosis therapy. Leder BZ. JBMR Plus. 2018;2:62-8. DOI: https://doi.org/10.1002/jbm4.10041
Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002;359:1761-7. DOI: https://doi.org/10.1016/S0140-6736(02)08657-9
Ramalingaiah A, Sridhar R. Study of effect of zoledronic acid in patients with low back pain associated with vertebral osteoporosis. Int J Orthop Traumatol Surg Sci. 2016;2(2):367-70.
Umesh M, Prabhu Ethiraj, Siyad MN, Agarawal S, Shanthappa AH. Does zoledronic acid provide a good clinical outcome in patients with chronic back pain associated with vertebral osteoporosis? Cureus. 2023;15(1):1-9. DOI: https://doi.org/10.7759/cureus.33328
Nayak K, Waghmare A, Jagdale AS, Chandrakar A, Gupta VK. Evaluation of the effect of zoledronic acid on back pain in patients with osteoporosis in the Tertiary Care Teaching Hospital of Chhattisgarh. J Cardiovasc Dis Res. 2024;15(6):4206-15.
Koivisto K, Kyllönen E, Haapea M. Efficacy of zoledronic acid for chronic low back pain associated with Modic changes in magnetic resonance imaging. BMC Musculoskelet Disord. 2014;15:64. DOI: https://doi.org/10.1186/1471-2474-15-64
Tu KN, Lie JD, Wan CK. Osteoporosis: a review of treatment options. P T. 2018;43:92-104.
Orwoll ES, Miller PD, Adachi JD. Efficacy and safety of a once-yearly i.v. Infusion of zoledronic acid 5 mg versus a once-weekly 70-mg oral alendronate in the treatment of male osteoporosis: a randomized, multicenter, double-blind, active-controlled study. J Bone Miner Res. 2010;25:2239-50. DOI: https://doi.org/10.1002/jbmr.119
Cauley JA, Black D, Boonen S. Once-yearly zoledronic acid and days of disability, bed rest, and back pain: randomized, controlled HORIZON Pivotal Fracture Trial. J Bone Miner Res. 2011;26:984-92. DOI: https://doi.org/10.1002/jbmr.292
Heller GZ, Manuguerra M, Chow R. How to analyze the Visual Analogue Scale: Myths, truths and clinical relevance. Scand J Pain. 2016;13:67-75. DOI: https://doi.org/10.1016/j.sjpain.2016.06.012
Baradaran A, Ebrahimzadeh MH, Birjandinejad A, Kachooei AR. Testing of the Modified Oswestry Disability Questionnaire in Persian Population with Low Back Pain. Asian Spine J. 2016;10(2):215-9. DOI: https://doi.org/10.4184/asj.2016.10.2.215