Incidence and risk factors of adjacent segment disease following short segment posterior instrumentation in Bahraini patients: a five-year retrospective analysis
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20251119Keywords:
Adjacent segment disease, Adjacent disc degeneration, MRI, Risk factors, Short segment spinal fusionAbstract
Background: Despite advances in spinal surgery, adjacent segment disease (ASD) and adjacent disc degeneration (ADD) remain notable postoperative complications following spinal fusion, mainly due to suspected increased biomechanical stress that leads to adjacent disc degeneration. This research focuses on the Bahraini population, utilizing MRI to compare pre-op and post-op Adjacent disc conditions to identify the incidence and risk factors of ASD and ADD after short segment spinal fusion.
Methods: A retrospective cohort study conducted over a five-year period at Salmaniya Medical Complex, the largest tertiary care center in the Kingdom of Bahrain. Reviewing pre-operative and post-operative MRI scans of 41 symptomatic patients who underwent short segment spinal fusion between 2014 and 2019. Patients were selected based on specific pre-operative and post-operative criteria developed by the orthopaedic team and were followed up to October 2023. Statistical analyses were performed using R software.
Results: The analysis of 41 patients revealed a significant incidence of adjacent segment changes and the main risk factor that showed significance was advancing age. While other reported risk factors like level of fusion and number of fused segments did not significantly correlate with advancing ADD or ASD. There was no statistically significant association between hypertension, diabetes or multiple comorbidities and worsening conditions for either ASD or ADD post operation.
Conclusions: The findings from our study contribute to the understanding of ASD and ADD after lumbar fusion surgeries, particularly in highlighting the significance of age. These insights can aid surgeons in better anticipating the risks associated with specific demographic and clinical profiles. More controlled studies on larger populations will help delineate more concrete risk factors.
Metrics
References
Bagheri SR, Alimohammadi E, Zamani Froushani A, Abdi A. Adjacent segment disease after posterior lumbar instrumentation surgery for degenerative disease: Incidence and risk factors. J of Orthopaedic Surg. 2019;2;27(2):984237. DOI: https://doi.org/10.1177/2309499019842378
Chou D, Dekutoski M, Hermsmeyer J, Norvell DC. The Treatment of Lumbar Adjacent Segment Pathology After a Previous Lumbar Surgery. Spine. 2012;37:180–8. DOI: https://doi.org/10.1097/BRS.0b013e31826d613d
Kushchayev S V., Glushko T, Jarraya M, Schuleri KH, Preul MC, Brooks ML, et al. ABCs of the degenerative spine. Insights Imaging. 2018;9(2):253–74. DOI: https://doi.org/10.1007/s13244-017-0584-z
Olvera AGR, Arroyo MV, Martínez LMH, Pérez EM, Hinojosa LRR. Adjacent segment disease in degenerative pathologies with posterior instrumentation. Coluna/Columna. 2015;14(1):23–6. DOI: https://doi.org/10.1590/S1808-1851201514010R122
Pfirrmann CWA, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration. Spine. 2001;26(17):1873–8. DOI: https://doi.org/10.1097/00007632-200109010-00011
R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria. 2021.
Alentado VJ, Lubelski D, Healy AT, Orr RD, Steinmetz MP, Benzel EC, et al. Predisposing Characteristics of Adjacent Segment Disease After Lumbar Fusion. Spine. 2016;15(14):1167–72. DOI: https://doi.org/10.1097/BRS.0000000000001493
Anandjiwala J, Seo JY, Ha KY, Oh IS, Shin DC. Adjacent segment degeneration after instrumented posterolateral lumbar fusion: a prospective cohort study with a minimum five-year follow-up. European Spine J. 2011;22(11):1951–60. DOI: https://doi.org/10.1007/s00586-011-1917-0
Bydon M, Xu R, Santiago-Dieppa D, Macki M, Sciubba DM, Wolinsky JP, et al. Adjacent-segment disease in 511 cases of posterolateral instrumented lumbar arthrodesis: floating fusion versus distal construct including the sacrum. J Neurosurg Spine. 2014;20(4):380–6. DOI: https://doi.org/10.3171/2013.12.SPINE13789
Cheh G, Bridwell KH, Lenke LG, Buchowski JM, Daubs MD, Kim Y, et al. Adjacent segment disease following lumbar/thoracolumbar fusion with pedicle screw instrumentation. Spine. 2007;32(20):2253–7. DOI: https://doi.org/10.1097/BRS.0b013e31814b2d8e
Chen BL, Wei FX, Ueyama K, Xie DH, Sannohe A, Liu SY. Adjacent segment degeneration after single-segment PLIF: the risk factor for degeneration and its impact on clinical outcomes. European Spine J. 2011;1(11):1946–50. DOI: https://doi.org/10.1007/s00586-011-1888-1
Zencica P, Chaloupka R, Hladíková J, Krbec M. Adjacent segment degeneration after lumbosacral fusion in spondylolisthesis: a retrospective radiological and clinical analysis. Acta Chir Orthop Traumatol Cech. 2010;77(2):124-130. DOI: https://doi.org/10.55095/achot2010/023
Zhong ZM, Deviren V, Tay B, Burch S, Berven SH. Adjacent segment disease after instrumented fusion for adult lumbar spondylolisthesis: Incidence and risk factors. Clin Neurol Neurosurg. 2017;156:29–34. DOI: https://doi.org/10.1016/j.clineuro.2017.02.020
Kim JY, Ryu DS, Paik HK, Ahn SS, Kang MS, Kim KH, et al. Paraspinal muscle, facet joint and disc problems: risk factors for adjacent segment degeneration after lumbar fusion. The Spine J. 2016;16(7):867–75. DOI: https://doi.org/10.1016/j.spinee.2016.03.010
Korovessis P, Repantis T, Zacharatos S, Zafiropoulos A. Does Wallis implant reduce adjacent segment degeneration above lumbosacral instrumented fusion? European Spine J. 2009;18(6):830–40. DOI: https://doi.org/10.1007/s00586-009-0976-y
Kumar M, Baklanov A, Chopin D. Correlation between sagittal plane changes and adjacent segment degeneration following lumbar spine fusion. European Spine J. 2001;10(4):314–9. DOI: https://doi.org/10.1007/s005860000239
Lawrence BD, Wang J, Arnold PM, Hermsmeyer J, Norvell DC, Brodke DS. Predicting the risk of adjacent segment pathology after lumbar fusion. Spine. 2012;37:123–32. DOI: https://doi.org/10.1097/BRS.0b013e31826d60d8
Lee CH, Hyun SJ, Kim KJ, Jahng TA, Yoon SH, Kim HJ. The efficacy of lumbar hybrid stabilization using the DIAM to delay adjacent segment degeneration. operative neurosurg. 2013;73:224–32. DOI: https://doi.org/10.1227/NEU.0b013e31828e8ddc
Liang J, Dong Y, Zhao H. Risk factors for predicting symptomatic adjacent segment degeneration requiring surgery in patients after posterior lumbar fusion. J Orthop Surg Res. 2014;12;9(1):97. DOI: https://doi.org/10.1186/s13018-014-0097-0
Lu K, Liliang PC, Wang HK, Liang CL, Chen JS, Chen TB, et al. Reduction in adjacent-segment degeneration after multilevel posterior lumbar interbody fusion with proximal DIAM implantation. J Neurosurg Spine. 2015;23(2):190–6. DOI: https://doi.org/10.3171/2014.12.SPINE14666
Nagata H, Schendel MJ, Transfeldt EE, Lewis JL. The Effects of Immobilization of Long Segments of the Spine on the Adjacent and Distal Facet Force and Lumbosacral Motion. Spine. 1993;18(16):2471–9. DOI: https://doi.org/10.1097/00007632-199312000-00017
Oda I, Cunningham BW, Buckley RA, Goebel MJ, Haggerty CJ, Orbegoso CM, et al. Does Spinal Kyphotic Deformity Influence the Biomechanical Characteristics of the Adjacent Motion Segments. Spine. 1999;24(20):2139. DOI: https://doi.org/10.1097/00007632-199910150-00014
Okuda S, Iwasaki M, Miyauchi A, Aono H, Morita M, Yamamoto T. Risk Factors for Adjacent Segment Degeneration After PLIF. Spine. 2004;29(14):1535–40. DOI: https://doi.org/10.1097/01.BRS.0000131417.93637.9D
Park P, Garton HJ, Gala VC, Hoff JT, McGillicuddy JE. Adjacent Segment Disease after Lumbar or Lumbosacral Fusion: Review of the Literature. Spine. 2004;29(17):1938–44. DOI: https://doi.org/10.1097/01.brs.0000137069.88904.03
Penta M, Sandhu A, Fraser RD. Magnetic Resonance Imaging Assessment of Disc Degeneration 10 Years After Anterior Lumbar Interbody Fusion. Spine. 1995;20(6):743–7. DOI: https://doi.org/10.1097/00007632-199503150-00018
Scemama C, Magrino B, Gillet P, Guigui P. Risk of adjacent-segment disease requiring surgery after short lumbar fusion: results of the French Spine Surgery Society Series. J Neurosurg Spine. 2016;25(1):46–51. DOI: https://doi.org/10.3171/2015.11.SPINE15700
Soh J, Lee JC, Shin BJ. Analysis of Risk Factors for Adjacent Segment Degeneration Occurring More than 5 Years after Fusion with Pedicle Screw Fixation for Degenerative Lumbar Spine. Asian Spine J. 2013;7(4):273. DOI: https://doi.org/10.4184/asj.2013.7.4.273
Umehara S, Zindrick MR, Patwardhan AG. The biomechanical effect of postoperative hypolordosis in instrumented lumbar fusion on instrumented and adjacent spinal segments. Spine (Phila Pa 1976). 2000;13:1617–24.
Wang T, Ding W. Risk factors for adjacent segment degeneration after posterior lumbar fusion surgery in treatment for degenerative lumbar disorders: a meta-analysis. J Orthop Surg Res. 2020;15(1):582. DOI: https://doi.org/10.1186/s13018-020-02032-7
Wang JC, Arnold PM, Hermsmeyer JT, Norvell DC. Do lumbar motion preserving devices reduce the risk of adjacent segment pathology compared with fusion surgery. a systematic review. Spine. 2012;37:133–43. DOI: https://doi.org/10.1097/BRS.0b013e31826cadf2
Weinhoffer SL, Guyer RD, Herbert M, Griffith SL. Intradiscal Pressure Measurements Above an Instrumented Fusion. Spine. 1995;20(5):526–31. DOI: https://doi.org/10.1097/00007632-199503010-00004
Wiltse LL, Radecki SE, Biel HM. Comparative study of the incidence and severity of degenerative change in the transition zones after instrumented versus noninstrumented fusions of the lumbar spine. J Spinal Disord. 1999;12(1):27–33. DOI: https://doi.org/10.1097/00002517-199902000-00004
Yamasaki K, Hoshino M, Omori K, Igarashi H, Nemoto Y, Tsuruta T, et al. Risk factors of adjacent segment disease after transforaminal inter-body fusion for degenerative lumbar disease. Spine. 2017;42(2):86–92. DOI: https://doi.org/10.1097/BRS.0000000000001728
Trivedi NN, Wilson SM, Puchi LA, Lebl DR. Evidence-based analysis of adjacent segment degeneration and disease after LIF: A Narrative Review. Global Spine J. 2018;8(1):95–102. DOI: https://doi.org/10.1177/2192568217734876
Calcagni E, Sarramea H. Survivorship analysis of Adjacent Segment Disease (ASD) in lumbar arthrodesis. Lecture in Spineweek, Amsterdam, Holland. In Amsterdam. 2012.
Umehara S, Zindrick MR, Patwardhan AG, Havey RM, Vrbos LA, Knight GW, et al. The Biomechanical Effect of Postoperative Hypolordosis in Instrumented Lumbar Fusion on Instrumented and Adjacent Spinal Segments. Spine (Phila Pa 1976). 2000;25(13):1617–24. DOI: https://doi.org/10.1097/00007632-200007010-00004
Fukaya K, Hasegawa M, Shirato M, Teshima T. Risk Factors for Predicting the Need for Additional Surgery for Symptomatic Adjacent Segment Disease after Minimally Invasive Surgery-Transforaminal Lumbar Interbody Fusion. No Shinkei Geka. 2017;4:311–9.
Ghasemi AA. Adjacent segment degeneration after posterior lumbar fusion: An analysis of possible risk factors. Clin Neurol Neurosurg. 2016;143:15–8. DOI: https://doi.org/10.1016/j.clineuro.2016.02.004
Ghiselli G, wang JC, bhatia NN, Hsu WK, Dawson EG. Adjacent segment degeneration in the lumbar spine. The J of Bone and Joint Surgery-American. 2004;86(7):1497–503. DOI: https://doi.org/10.2106/00004623-200407000-00020
Kawaguchi Y, Ishihara H, Kanamori M, Yasuda T, Abe Y, Nogami S, et al. Adjacent segment disease following expansive lumbar laminoplasty. The Spine J. 2007;7(3):273–9. DOI: https://doi.org/10.1016/j.spinee.2006.04.003
Chung KJ, Suh SW, Swapnil K, Yang JH, Song HR. Facet joint violation during pedicle screw insertion: a cadaveric study of the adult lumbosacral spine comparing the two pedicle screw insertion techniques. Int Orthop. 2007;10(5):653–6. DOI: https://doi.org/10.1007/s00264-006-0249-x
Etebar S, Cahill DW. Risk factors for adjacent-segment failure following lumbar fixation with rigid instrumentation for degenerative instability. J Neurosurg Spine. 1999;90(2):163–9. DOI: https://doi.org/10.3171/spi.1999.90.2.0163
Ouchida J, Nakashima H, Kanemura T, Matsubara Y, Satake K, Muramoto A, et al. Adjacent Segment Degeneration after Short-Segment Lateral Lumbar Interbody Fusion (LLIF). Biomed Res Int. 2022;2:1–5. DOI: https://doi.org/10.1155/2022/3407681