A current concept review of 9 year old boy with hemophilic arthropathy
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20250469Keywords:
Hemophilic arthropathy, Factor replacement therapy, Chronic hemophilic synovitis, SynoviorthesisAbstract
The knee is frequently affected by severe orthopedic changes known as hemophilic arthropathy (HA) in patients with deficiency of coagulation factor VIII or IX and thus this manuscript seeks to present a current perspective of the role of the orthopedist, physiotherapist and pathologist in the management of these problems. Lifelong factor replacement therapy (FRT) is optimal to prevent HA, however adherence to this rigorous treatment is challenging leading to breakthrough bleeding. In patients with chronic hemophilic synovitis, the prelude to HA, Synoviorthesis is the optimal to ameliorate bleeding, judicious physiotherapy to prevent chronic joint disease.
Metrics
References
Rosner F. Hemophilia in the Talmud and Rabbinic writings. Ann Intern Med. 1986;70(4):833-7. DOI: https://doi.org/10.7326/0003-4819-70-4-833
Ingram GIC. The history of hemophilia. J Clin Pathol. 1976;29(6):469-79. DOI: https://doi.org/10.1136/jcp.29.6.469
Hoyer LW. Hemophilia A. N Engl J Med. 1994;330(1):38-47. DOI: https://doi.org/10.1056/NEJM199401063300108
Kerr CB, Preston AE, Barr A, Biggs R. further studies on the inheritance of factor VIII. Br J Haematol 1966;12(2):212-33. DOI: https://doi.org/10.1111/j.1365-2141.1966.tb05627.x
Davies SH, Gavin J, Goldsmith KLG, Graham JB, Hamper J, Hardisty RM, et al. The linkage relations of hemophilia A and hemophilia B (Christmas disease) to the Xg blood group system. Am J Hum Genet. 1963;15(4):481-92.
Graham JB. Genetic control of factor VIII. Lancet 1980;1(4164):340-2. DOI: https://doi.org/10.1016/S0140-6736(80)90887-9
Gilbert MS. Musculoskeletal manifestations of hemophilia. Mt Sinai J Med. 1977;44(3):339-58.
Van Creveld S, Kingma MJ. Subperiosteal haemorrhage in haemophila A and B. Acta Paediatr (Scand). 1961;50:291-6. DOI: https://doi.org/10.1111/j.1651-2227.1961.tb08175.x
Gilbert MS. Prophylaxis: musculoskeletal evaluation. Semin Hematol. 1993;30(3-2):3-6.
Manco-Johnson MJ, Pettersson H, Petrini P, Babyn PS, Bergstrom BM, Bradley CS, et al. Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directions. Haemophilia. 2004;10(4):88-93. DOI: https://doi.org/10.1111/j.1365-2516.2004.00978.x
Arnold WD, Hilgartner MW. Hemophilic arthropathy. Current concepts of pathogenesis and management. J Bone Joint Surg Am. 1977;59(3):287-305. DOI: https://doi.org/10.2106/00004623-197759030-00001
Pettersson H, Ahlberg A, Nilsson IM. A radiologic classification of hemophilic arthropathy Clin Orthop Relat Res. 1980:(149):153-9. DOI: https://doi.org/10.1097/00003086-198006000-00018
Downloads
Published
How to Cite
Issue
Section
