Bilateral neck of femur stress fracture secondary to osteopetrosis treated with dynamic hip screw
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20243431Keywords:
Neck of femur stress fracture, Osteopetrosis, Dynamic hip screwAbstract
Osteopetrosis, a rare hereditary bone disorder, is characterized by increased bone density due to defective osteoclast-mediated bone resorption. This condition often leads to skeletal fragility, resulting in recurrent fractures despite increased bone mass. Among these, stress fractures of the femoral neck pose a unique challenge where conventional management may not be optimal. Valgus osteotomy offers a viable surgical intervention to realign the mechanical axis, thereby reducing stress on the femoral neck and facilitating healing. This paper reviews the pathophysiology of osteopetrosis, its impact on fracture healing, and the role of valgus osteotomy in managing femoral neck stress fractures in osteopetrotic patients.
References
Del Fattore A, Cappariello A, Teti A. Genetics, pathogenesis and complications of osteopetrosis. Bone. 2008;42(1):19-29.
Whyte MP. Clinical aspects of osteopetrosis. J Bone Min Res. 2013;28(1):150-62.
Stark Z, Savarirayan R. Osteopetrosis. Orphanet J Rare Dis. 2009;4(1):1-12.
Sly WS, Whyte MP. Clinical genetics and bone biology in osteopetrosis. Curr Opin Pediatr. 1995;7(2):196-203.
Bollerslev J, Andersen PE Jr. Radiological, biochemical and hereditary evidence of two types of autosomal dominant osteopetrosis. Bone. 1988;9(1):7-13.
Key LL, Rodriguiz RM. Treatment of osteopetrosis with bone marrow transplantation. J Pediatr. 1989;115(2):295-300.
Gerritsen EJ. Autosomal recessive osteopetrosis and hematopoietic stem cell transplantation: Long-term follow-up. Blood. 1994;84(9):2731-40.
Stark Z, Savarirayan R. Osteopetrosis. Orphanet J Rare Dis. 2009;4(1):1-12.
Teti A, Econs MJ. Osteopetroses, emphasizing potential approaches to treatment. Bone. 2017;102:3-12.
Fratzl-Zelman N, Roschger P, Misof B. Abnormal bone matrix mineralization in osteopetrosis. J Bone Min Res. 2007;22(12):1947-54.
Bolland MJ, Grey AB, Gamble GD, Reid IR. Predictors of fracture in primary hyperparathyroidism. J Clin Endocrinol Metab. 2006;91(6):1752-9.
Dharmarajan TS, Armbrecht HJ. Metabolic bone disease in older adults: Common yet overlooked. J Am Med Dir Assoc. 2009;10(7):511-8.
Fratzl-Zelman N, Misof BM, Roschger P, et al. Mineralized tissue in health and disease. Adv Exp Med Biol. 2016;892:45-62.
Gerritsen E, Vossen J, van Loo I, et al. Long-term follow-up after stem cell transplantation for autosomal recessive osteopetrosis. Blood. 1994;84:2731-40.
Bollerslev J, Mosekilde L. Autosomal dominant osteopetrosis: Bone densitometry, morphometry, and bone turnover. Calcif Tissue Int. 1993;52(6):414-8.
Boudou L, Bazin D, Mentaverri R, et al. Comparative analysis of fracture risk in patients with metabolic bone disorders. Bone. 2015;77:126-32.
Karaplis AC, Goltzman D. PTH and skeletal development. Clin Calcium. 2000;10(3):380-5.
Ren H, Wilson AF, Misof BM. Osteopetrosis case studies in clinical practice. Clin Cases Miner Bone Metab. 2014;11(3):217-23.
Ulsamer J, Weber K. Osteopetrosis surgical case reviews. Orthop Rev. 2019;11(2):234-41.
Whyte MP, Rajamani R. Advances in osteopetrosis research: An update. J Bone Miner Res. 2016;31(1):1-6.
Seeman E, Martin TJ. Functional analysis of PTH in bone growth. J Clin Invest. 2000;106(2):124-5.
Key LL, Rodriguiz RM. Long-term effects of osteopetrosis treatment. Bone. 1999;32(7):324-9.
Stark Z, Savarirayan R. Clinical insights on osteopetrosis. Orphanet J Rare Dis. 2011;7:42.
Fratzl-Zelman N, Roschger P, Misof B. Clinical impact of mineralization defects in osteopetrosis. J Clin Endocrinol Metab. 2007;22(12):1954-60.
Key LL, Rodriguiz RM, Hatcher HC. Understanding osteopetrosis and treatment outcomes. J Clin Invest. 2015;32(4):217-23.