Static antibiotic loaded cement spacer application in 2-stage management of native and prosthetic hip joint infections: a case series and review of the literature
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20250462Keywords:
Cement spacer, Haemoglobinopathy, Arthroplasty, AntibioticsAbstract
Two-stage revision including interval cement spacer application is the gold standard treatment for both prosthetic and native hip infection with joint destruction. We present a summarised case series of our experience of successfully treating 8 infected joints in 6 patients treated with 2-stage revision using interval static spacers. Two patients with 3 native joint infections and 4 patients with 5 prosthetic joint infections were treated with 2-stage arthroplasty with interval static spacer application consisting of static block spacers or cement beads. There were 2 females and 4 males. Mean age is 40.5 years and range 24-60 years. Mean interval between the first and second stage is 8weeks. One case has not undergone the second stage as he is unable to fund the operation. Organisms cultured include methicillin- sensitive staphylococcus aureus, enterococcus. All underwent cementless hip reconstruction with one patient undergoing hybrid hip reconstruction. At mean 36-month follow-up (range 30-44 months) all patients have normalized inflammatory markers and improvement in Oxford hip score (OHS) from pre-operative mean 16.6 (range 15-19) and post-operative mean OHS 43.7 (range 35-50). Patients continue to be followed up. We recommend this cement spacer option as part of a 2-stage procedure when faced with moderate to severe acetabular bone loss. It is effective in treating native or prosthetic hip joint infections and joint infections in patients with sickle cell haemoglobinopathy.
Metrics
References
Biring GS, Kostamo T, Garbuz DS, Masri BA, Duncan CP. Two-stage revision arthroplasty of the hip for infection using an interim articulated Prostalac hip spacer: a 10- to 15-year follow-up study. J Bone Joint Surg Br. 2009;91(11):1431-7. DOI: https://doi.org/10.1302/0301-620X.91B11.22026
Hsieh PH, Shih CH, Chang YH, Lee MS, Shih HN, Yang WE. Two-stage revision hip arthroplasty for infection: comparison between the interim use of antibiotic-loaded cement beads and a spacer prosthesis. J Bone Joint Surg Am. 2004;86(9):1989-97. DOI: https://doi.org/10.2106/00004623-200409000-00018
Paprosky WG, Perona PG, Lawrence JM. Acetabular defect classification and surgical reconstruction in revision arthroplasty a 6-year follow-up evaluation. J Arthroplasty. 1994;9(1):33-44. DOI: https://doi.org/10.1016/0883-5403(94)90135-X
Dawson J, Fitzpatrick R, Carr A, Murray D. Questionnaire on the perceptions of patients about total hip replacement. J Bone Joint Surg Br. 1996;78(2):185-90. DOI: https://doi.org/10.1302/0301-620X.78B2.0780185
Anagnostakos K, Kelm J. Enhancement of antibiotic elution from acrylic bone cement. J Biomed Mater Res B Appl Biomater. 2009;90(01):467-75. DOI: https://doi.org/10.1002/jbm.b.31281
Learmonth ID, Young C, Rorabeck C. The operation of the century: total hip replacement. Lancet. 2007;370(9597):1508-19. DOI: https://doi.org/10.1016/S0140-6736(07)60457-7
Salaffi F, Carotti M, Grassi W. Health-related quality of life in patients with hip or knee osteoarthritis: comparison of generic and disease-specific instruments. Clin Rheumatol. 2005;24:29-37. DOI: https://doi.org/10.1007/s10067-004-0965-9
Kurtz S, Ong K, Lau E, Watson H, Schmier JK, Parvizi J. Economic burden of periprosthetic joint infection in the United States. J Arthroplasty. 2012;27(8):61-5. DOI: https://doi.org/10.1016/j.arth.2012.02.022
Kunze KN, Alexander S, Kerzner BS, Levine BR. Two-Stage Primary Arthroplasty of Native Hips and Knees that had Previously Failed Treatment for Septic Arthritis: A Single Centre Experience. Arthoplasty Today. 2020;6(3):431-6. DOI: https://doi.org/10.1016/j.artd.2020.05.012
Citak M, Argenson JN, Masri B, Taunton MJ, Vogely CH, Wellman SS, et al. Spacers. J Orthop Res. 2014;32(1):S120-9.
Anagnostakos K, Wilmes P, Schmitt E, Kelm J. Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo. Acta Orthop. 2009;80:193-7. DOI: https://doi.org/10.3109/17453670902884700
Masri BA, Duncan CP, Beauchamp CP. Long-term elution of antibiotics from bone-cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system. J Arthroplasty. 1998;13(03):331-8. DOI: https://doi.org/10.1016/S0883-5403(98)90179-6
Jacobs C, Christensen CP, Berend ME. Static and mobile antibiotic-impregnated cement spacers for the management of prosthetic joint infection. J Am Acad Orthop Surg. 2009;17(6):356-68. DOI: https://doi.org/10.5435/00124635-200906000-00004
Moerenhout K, Steinmetz S, Vautrin M, Picarra S, Udin G, Borens O. Economic advantage of 'self-made' antibiotic-loaded spacer compared to prefabricated antibiotic-loaded spacer and spacer molds in two-staged revision arthroplasty. Acta Orthop Belg. 2021;87(3):557-62. DOI: https://doi.org/10.52628/87.3.24
Bertazzoni Minelli E, Benini A, Magnan B, Bartolozzi P. Release of gentamicin and vancomycin from temporary human hip spacers in two-stage revision of infected arthroplasty. J Antimicrob Chemother. 2004;53(2):329-34. DOI: https://doi.org/10.1093/jac/dkh032
James A, Larson T. Acute renal failure after high-dose antibiotic bone cement: case report and review of the literature. Ren Fail. 2015;37(6):1061-6. DOI: https://doi.org/10.3109/0886022X.2015.1052949