Advances in stem cell therapy for articular cartilage lesions: clinical evidence and future directions: a systematic review

Kevin Miranda Suárez; Claudia Anabel Pesantez Zea; Mateo Daniel Fabara Vera; Bryan Steven Pasquel Rodríguez; Andrea Janet Zambrano Garces; Erick Santiago Velastegui Jijón; Angel Eduardo Romo Quintana; Katherine Lizeth  Bautista Suárez

doi:10.18203/issn.2455-4510.IntJResOrthop20240935

Authors

Kevin Miranda Suárez Department of Orthopedics, NOVA Clínica Santa Cecilia, Ecuador https://orcid.org/0000-0002-9357-4067
Claudia Anabel Pesantez Zea Department of Medicine, Universidad Catolica Azogues, Ecuador https://orcid.org/0009-0003-4045-9529
Mateo Daniel Fabara Vera Department of Medicine, Universidad De Las Américas, Ecuador https://orcid.org/0009-0003-4052-6162
Bryan Steven Pasquel Rodríguez Department of Medicine, Universidad De Las Américas, Ecuador https://orcid.org/0000-0002-8905-0068
Andrea Janet Zambrano Garces Department of Medicine, Universidad De Guayaquil, Ecuador https://orcid.org/0009-0006-3264-2667
Erick Santiago Velastegui Jijón Department of Aesthetic Medicine, Nutrition and Anti-aging, Distance University of Madrid (UDIMA), Spain https://orcid.org/0009-0008-5501-2750
Angel Eduardo Romo Quintana Department of Medicine, Universidad Central, Ecuador https://orcid.org/0009-0004-6777-5625
Katherine Lizeth Bautista Suárez Department of Medicine, Ministerio De Salud Pública, Ecuador https://orcid.org/0000-0002-6010-3154

DOI:

https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20240935

Keywords:

Stem cell therapy, Articular cartilage lesions, Cartilage

Abstract

The significance of articular cartilage, an essential connective tissue, cannot be overstated in relation to joint health and functionality. Nevertheless, the human body might have adverse effects due to traumatic incidents, degenerative conditions, or repetitive stress, resulting in the manifestation of pain, inflammation, and impaired functionality. The primary objective of this study is to assess the effectiveness of stem cell therapy in the treatment of articular cartilage damage such as lesions. The systematic review was conducted adhering to the PRISMA principles. Boolean logic is employed in the search technique to integrate phrases pertaining to stem cell therapy, articular cartilage diseases, and biological processes. The research employs a range of databases and medical subject headings (MeSH) in order to facilitate a thorough examination. The stem cell therapy in the treatment of articular cartilage lesions has great potential. It enhances management and treatment outcomes for individuals afflicted with cartilage abnormalities. It is beneficial particularly those diagnosed with osteoarthritis (OA). Encouraging outcomes, such as alleviation of pain and improvement in functionality have been reported. Additional investigation is required to enhance therapy regimens, encompassing cell dosage, delivery techniques, and supplementary medicines. The use of stem cell therapies necessitates the imperative collaboration among researchers, doctors and regulatory agencies.

Metrics

Metrics Loading ...

References

Jiang S, Tian G, Li X, Yang Z, Wang F, Tian Z, et al. Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration. Stem Cells Int. 2021;1-25.

Merkely G, Ackermann J, Lattermann C. Articular Cartilage Defects: Incidence, Diagnosis, and Natural History. Operative Techn Sports Med. 2018;26(3):156-61.

Jiang B, Fu X, Yan L, Li S, Zhao D, Wang X, et al. Transplantation of human ESC-derived mesenchymal stem cell spheroids ameliorates spontaneous osteoarthritis in rhesus macaques. Theranostics. 2019;9(22):6587-600.

Razak HRBA, Corona K, Totlis T, Chan LYT, Salreta JF, Sleiman O, et al. Mesenchymal stem cell implantation provides short‐term clinical improvement and satisfactory cartilage restoration in patients with knee osteoarthritis but the evidence is limited: a systematic review performed by the early‐osteoarthritis group of ESSKA‐European knee associates section. Knee Surg Sports Traumatol Arthroscopy. 2023;31(12):5306-18.

Gan J, Deng X, Le Y, Lai J, Liao X. The Development of Naringin for Use against Bone and Cartilage Disorders. Molecules. 2023;28(9):3716.

Wodzig M, Peters M, Emanuel K, Van Hugten P, Wijnen W, Jutten L, et al. Minced Autologous Chondral Fragments with Fibrin Glue as a Simple Promising One-Step Cartilage Repair Procedure: A Clinical and MRI Study at 12-Month Follow-Up. Cartilage. 2022;13(4):19-31.

Moradi M, Parvizpour F, Arabpour Z, Zargarzadeh N, Nazari M, Rashnavadi H, et al. Articular Cartilage Injury; Current Status and Future Direction. Current Stem Cell Res Therapy. 2024;19(5):653-61.

Matsushita T, Tokura T, Okimura K, Sano S, Nishida K, Nagai K, et al. Surgical treatment of cartilage lesions in the knee: A narrative review. J Joint Surg Res. 2023;1(1):70-9.

Moradi M, Parvizpour F, Arabpour Z, Zargarzadeh N, Nazari M, Rashnavadi H, et al. Articular Cartilage Injury; Current Status and Future Direction. Curr Stem Cell Res Therapy. 2024;19(5):653-61.

Campbell MP, Sonnier JH, Wright ML, Freedman KB. Surgical Management of Failed Articular Cartilage Surgery in the Knee. Orthopedics, 2023;46(5):262-72.

Carneiro DDC, Araújo LTD, Santos GC, Damasceno PKF, Vieira JL, Santos RRD, et al. Clinical Trials with Mesenchymal Stem Cell Therapies for Osteoarthritis: Challenges in the Regeneration of Articular Cartilage. Int J Molecular Sci. 2023;24(12):9939.

Lv Z, Cai X, Bian Y, Wei Z, Zhu W, Zhao X, et al. Advances in Mesenchymal Stem Cell Therapy for Osteoarthritis: From Preclinical and Clinical Perspectives. Bioengineering. 2023;10(2):195.

Thoene M, Bejer-Olenska E, Wojtkiewicz J. The Current State of Osteoarthritis Treatment Options Using Stem Cells for Regenerative Therapy: A Review. Int J Molecular Sci. 2023;24(10):8925.

Sarkis-Onofre R, Catalá-López F, Aromataris E, Lockwood C. How to properly use the PRISMA Statement. Systematic Rev. 2021;10(1).

Morgan H. Conducting a Qualitative Document Analysis. The Qualitative Report. 2022.

Kim YS, Chung PK, Suh DS, Heo DB, Tak DH, Koh YG. Implantation of mesenchymal stem cells in combination with allogenic cartilage improves cartilage regeneration and clinical outcomes in patients with concomitant high tibial osteotomy. Knee Surg Sports Traumatol Arthroscopy. 2019;28(2):544-54.

Kim YS, Suh DS, Tak DH, Chung PK, Koh YG. Mesenchymal Stem Cell Implantation in Knee Osteoarthritis: Midterm Outcomes and Survival Analysis in 467 Patients. Orthop J Sports Med. 2020;8(12):232596712096918.

Yang HY, Song EK, Kang SJ, Kwak WK, Kang JK, Seon JK. Allogenic umbilical cord blood-derived mesenchymal stromal cell implantation was superior to bone marrow aspirate concentrate augmentation for cartilage regeneration despite similar clinical outcomes. Knee Surg Sports Traumatol Arthroscopy. 2021;30(1):208-18.

Song JS, Hong KT, Kim NM, Jung JY, Park HS, Lee SH, et al. Implantation of allogenic umbilical cord blood-derived mesenchymal stem cells improves knee osteoarthritis outcomes: Two-year follow-up. Regenerative Therapy. 2020;14:32-9.

Song JS, Hong KT, Kong CG, Kim NM, Jung JY, Park HS, et al. High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration. World J Stem Cells. 2020;12(6):514-26.

Jung WH, Takeuchi R, Chun CW, Lee JS, Ha JH, Kim JH, et al. Second-Look Arthroscopic Assessment of Cartilage Regeneration After Medial Opening-Wedge High Tibial Osteotomy. Arthroscopy J Arthroscop Rel Surg. 2014;30(1):72-9.

Wong KL, Lee KBL, Tai BC, Law P, Lee EH, Hui JH. Injectable Cultured Bone Marrow-Derived Mesenchymal Stem Cells in Varus Knees with Cartilage Defects Undergoing High Tibial Osteotomy: A Prospective, Randomized Controlled Clinical Trial With 2 Years’ Follow-up. Arthroscopy J Arthroscop Rel Surg. 2013;29(12):2020-28.

Koh YG, Kwon OR, Kim YS, Choi YJ. Comparative Outcomes of Open-Wedge High Tibial Osteotomy with Platelet-Rich Plasma Alone or in Combination with Mesenchymal Stem Cell Treatment: A Prospective Study. Arthroscopy J Arthroscopic Rel Surg. 2014;30(11):1453-60.

Koh YG, Kwon OR, Kim YS, Choi YJ. Comparative Outcomes of Open-Wedge High Tibial Osteotomy with Platelet-Rich Plasma Alone or in Combination With Mesenchymal Stem Cell Treatment: A Prospective Study. Arthroscopy J Arthroscop Rel Surg. 2014;30(11):1453-60.