Intra-articular autologous conditioned plasma reduces pain in early osteoarthritis and improves stiffness in advanced osteoarthritis knee: a prospective observation


  • Navin Tripathi Department of Orthopaedics, Manipal College of Medical Science, Fulbari, Pokhara, Gandaki, Nepal
  • Anil Regmi Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
  • Bhola Shrestha Department of Orthopaedics, Gandaki Medical College, Pokhara, Nayabazar, Gandaki, Nepal
  • Krishna Sapkota Department of Orthopaedics, Manipal College of Medical Science, Fulbari, Pokhara, Gandaki, Nepal
  • Dipesh Kayastha Department of Orthopaedics, Fishtail Hospital and Research Centre, Pokhara, Gairapatan, Gandaki, Nepal



Osteoarthritis, Intra-articular, Autologous conditioned plasma, WOMAC score, Outcome analysis


Background: In this study, we aimed to investigate the effects of single-dose intra-articular autologous conditioned plasma injection as the treatment for early and advanced osteoarthritis knee.

Methods: A single centre-based prospective observational analysis was conducted among patients who opt for conservative management by intra-articular autologous conditioned plasma Injection between July 2022 to June 2023. Total 46 patients were included and analysed in study on 1, 3, and 6 months’ follow-up after ACP injection. The WOMAC score and its sub scores were analysed and compared pre-procedure and on subsequent follow ups.

Results: A total of 46 patients were analysed in the study, with male predominance of 56.5% with mean BMI of 27.37±5.35. On KL grading, 34.8% patients had KL grade II Osteoarthritis, 52.2% had grade III and 13.0% had grade IV. On comparison of WOMAC score and its sub-scales, all the values were found to be statically significant while comparing before injection (p value <0.0001) and one month follow up and before injection and six months’ follow-up (p value <0.0001).

Conclusions: Six months following intra-articular autologous conditioned plasma injection, there was a noteworthy decrease in pain in early stages of osteoarthritis and improvement in knee stiffness in advanced stages of osteoarthritis as compared to the pre-treatment state.


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Original Research Articles