Skeletal involvement in Burkitt's lymphoma: a comprehensive review


  • Navin Tripathi Department of Orthopaedics, Manipal College of Medical Science Fulbari, Pokhara, Gandaki, Nepal
  • Anil Regmi Department of Orthopaedics, AIIMS, Rishikesh, Uttarakhand, India



BL, Orthopaedic manifestations, Skeletal involvement, Diagnosis, Treatment, Musculoskeletal system


Burkitt's lymphoma, a highly aggressive form of non-Hodgkin lymphoma, exhibits a distinctive predilection for rapid growth and systemic dissemination. While its primary manifestation is often observed in the lymphatic system, orthopaedic involvement has been increasingly recognized. This review synthesizes current literature to comprehensively explore the orthopaedic implications of Burkitt's lymphoma, encompassing clinical presentation, diagnostic challenges, treatment modalities, and associated outcomes.


Shapira J, Peylan-Ramu N. Burkitt’s Lymphoma. Oral Oncol. 1998;34(1):15-23.

Magrath IT. African Burkitt’s Lymphoma: History, Biology, Clinical Features, and Treatment. J Pediatr Hematol Oncol. 1991;13(2):222.

Fowles JV, Olweny CL, Katongole-Mbidde E, Lukanga-Ndawula A, Owor R. Burkitt’s lymphoma in the appendicular skeleton. J Bone Joint Surg Br. 1983;65-B(4):464-71.

Dashottar S, Sunita BS, Singh RK, Rana V, Suhag V, Singh AK. A case series of unusual presentations of Burkitt’s lymphoma. J Cancer Res Ther. 2020;16(1):66.

Kalisz K, Alessandrino F, Beck R, Smith D, Kikano E, Ramaiya NH et al. An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence. Insights Imaging. 2019;10(1):56.

Kuo YS, Wu YH, Sun A, Chiang CP. Burkitt’s lymphoma of the mandible. J Dent Sci. 2017;12(4):421-3.

Cha SM, Shin HD, Kim KC, Lee JK. A Girl with Limping Diagnosed as Burkitt Lymphoma. J Korean Orthop Assoc. 2014;49(1):64-8.

Cadavid L, Sastoque JM, Gutiérrez C, Yabur M, Molina G. Primary osseous Burkitt lymphoma with nodal and intracardiac metastases in a child. Radiol Case Rep. 2017;12(1):185-90.

Regmi A, Niraula BB, Dhingra G, Dhingra M. Successful conservative management of pelvic lytic lesion in a child with Burkitt’s Lymphoma: A rare case report. J Orthop Rep. 2022;1(4):100074.

Seo JY, Ha KY, Kim MU, Kim YC, Kim YH. Spinal cord compression by B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma in a patient seropositive for human immunodeficiency virus: a case report. J Med Case Rep. 2014;8(1):324.

Casado Picón R, Inocencio Arocena J de, Barrios López M, Vivanco Martínez JL. Burkitt’s lymphoma presenting as an intermittent limp. Reumatol Clínica Engl Ed. 2011;7(2):139-40.

Mechtoune M, Lahlimi FZ, Tazi I. Pathological fracture of the knee revealing Burkitt lymphoma: a case report. PAMJ Clin Med. 2021;5(81).

Iversen OH, Iversen U, Ziegler JL, Bluming AZ. Cell kinetics in Burkitt lymphoma. Eur J Cancer 1965. 1974;10(3):155-63.

Kelly GL, Rickinson AB. Burkitt Lymphoma: Revisiting the Pathogenesis of a Virus-Associated Malignancy. Hematology. 2007;2007(1):277-84.

Yagi S, Zheng R, Nishiyama S, Kawabata Y, Ise T, Sugiura K et al. Osteolytic primary bone lymphoma in the multiple bones. J Med Invest. 2019;66(3.4):347-50.

Levine AM. Challenges in the Management of Burkitt’s Lymphoma. Clin Lymphoma. 2002;3:S19-25.

Dunleavy K. Approach to the Diagnosis and Treatment of Adult Burkitt’s Lymphoma. J Oncol Pract. 2018;14(11):665-71.

Dave SS, Fu K, Wright GW, Lam LT, Kluin P, Boerma EJ et al. Molecular Diagnosis of Burkitt’s Lymphoma. N Engl J Med. 2006;354(23):2431-42.

Ferry JA. Burkitt’s Lymphoma: Clinicopathologic Features and Differential Diagnosis. The Oncologist. 2006;11(4):375-83.

Ziegler JL. Chemotherapy of Burkitt’s lymphoma. Cancer. 1972;30(6):1534-40.

Della Rocca AM, Leonart LP, Ferreira VL, Tonin FS, Steffenello-Durigon G, Del Moral JAG et al. Chemotherapy Treatments for Burkitt Lymphoma: Systematic Review of Interventional Studies. Clin Lymphoma Myeloma Leuk. 2021;21(8):514-25.

Ribrag V, Koscielny S, Bosq J, Leguay T, Casasnovas O, Fornecker LM et al. Rituximab and dose-dense chemotherapy for adults with Burkitt’s lymphoma: a randomised, controlled, open-label, phase 3 trial. Lancet. 2016;387(10036):2402-11.

Hoelzer D, Walewski J, Döhner H, Viardot A, Hiddemann W, Spiekermann K et al. Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial. Blood. 2014;124(26):3870-9.

Norin T, Onyango J. Radiotherapy in Burkitt’s lymphoma conventional or superfractionated regime-early results. Int J Radiat Oncol. 1977;2(5):399-406.

Dunleavy K, Pittaluga S, Shovlin M, Steinberg SM, Cole D, Grant C et al. Low-Intensity Therapy in Adults with Burkitt’s Lymphoma. N Engl J Med. 2013;369(20):1915-25.

Bonnet C, Janssens A, Wu KL, Schroyens W, Van Hende V, Heimann P et al. BHS guidelines for the treatment of Burkitt lymphoma. Belg J Hematol. 2015;6(2).

Kenkre VP, Stock W. Burkitt Lymphoma/Leukemia: Improving Prognosis. Clin Lymphoma Myeloma. 2009;9:S231-8.

Korszun A, Sarker SJ, Chowdhury K, Clark C, Greaves P, Johnson R et al. Psychosocial factors associated with impact of cancer in longterm haematological cancer survivors. Br J Haematol. 2014;164(6):790-803.






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