Arthrodesis following persistent periprosthetic knee infection using femoral condyle allograft: a case report and review of literature
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20240002Keywords:
Arthrodesis, Periprosthetic knee infection, Allograft, Case reportAbstract
Periprosthetic joint infections (PJI) of the knee are difficult to treat and can require costly and prolonged hospital stays, weeks or months of antibiotic therapy, and multiple surgical procedures. Knee arthrodesis is considered a last resort for persistent knee joint infections and provides stability and pain relief by fusing the knee joint. The authors describe a case of a persistent and difficult to treat periprosthetic total knee arthroplasty (TKA) infection, subjected to multiple surgeries and revisions, where an arthrodesis was performed as a last resort. The arthrodesis was performed using a femoral-tibial endomedullary nail with interposed femoral condyle allograft. Complete graft integration and consolidation was achieved without complications. The patient performed well post-operatively and is currently ambulatory with walking aids and has no knee pain. The removal of well-fixed metaphyseal sleeves in TKA can be challenging and associated with complications such as damage to the surrounding bone and soft tissue during the removal process. Taking special care and not rushing this step can present an extremely meaningful difference in the final outcome. In cases with large bone defects, especially after sleeve removal, allograft usage can be extremely useful for managing dead space and limb-length discrepancies while promoting faster bone healing. When successful, as was the case described, arthrodesis using allografts can have beneficial outcomes with high patient satisfaction and deliver function to previously very unhealthy joints and limbs.
References
Vasso M, Capasso L, Corona K, Pola E, Toro G, Schiavone Panni A. Periprosthetic knee infection: treatment options. Orthop Rev (Pavia). 2022;14(4):37537.
Kuiper JW, Willink RT, Moojen DJ, van den Bekerom MP, Colen S. Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts. World J Orthop. 2014;5(5):667-76.
Barretto JM, Campos ALS, Ooka NHM. Periprosthetic Knee Infection - Part 2: Treatment. Revista Brasileira De Ortopedia, 2022;57(2):193-9.
Zajonz D, Zimmerlich B, Möbius R, Edel M, Przybyl J, Höch A et al. Knee arthrodesis as last resort for persistent knee joint infections: Comparison of extramedullary and intramedullary treatment. Orthopade. 2021;50(3):207-13.
Boyd AD. Knee arthrodesis: indications and results of treatment. Current Opinion Orthop. 2000;11(1):14-8.
MacDonald JH, Agarwal S, Lorei MP, Johanson NA, Freiberg AA. Knee arthrodesis. J Am Acad Orthop Surg. 2006;14(3):154-63.
Matar HE, Bloch BV, James PJ. Role of metaphyseal sleeves in revision total knee arthroplasty: Rationale, indications and long-term outcomes. J Orthop. 2020;23:107-12.
Wong, W.K., Chua, H.S. The metaphyseal sleeve: an unexplored option in the treatment of complex primary knee osteoarthritis. Knee Surg Relat Res. 2020;32:20.
Kim K, Snir N, Schwarzkopf R. Modern Techniques in Knee Arthrodesis. Int J Orthop. 2016;3(1):487-96.
Tiemann AH. Knee arthrodesis-ultima ratio for the treatment of the infected knee. GMS Interdiscip Plast Reconstr Surg DGPW. 2013;2:Doc07.
Dennis DA. The structural allograft composite in revision total knee arthroplasty. J Arthroplasty. 2002;17(4-1):90-3.
Su AW, Chen WM, Chen CF, Chen TH. Innovative trident fixation technique for allograft knee arthrodesis for high-grade osteosarcoma around the knee. Jpn J Clin Oncol. 2009;39(11):739-44.
Robinson M, Piponov HI, Ormseth AH, Cory W, Schwartz B, Gonzalez MH. Knee Arthrodesis Outcomes After Infected Total Knee Arthroplasty and Failure of Two-stage Revision with an Antibiotic Cement Spacer. JAAOS: Global Research and Rev. 2018;2(1):e077.
Huang TL, Chen TH, Chen WY, Chen WM, Liu CL, Lo WH. Allograft arthrodesis of the knee in high-grade osteosarcoma. J Chin Med Assoc. 2005;68(9):425-30.
NA. Benefits and associated risks of using allograft, autograft and synthetic bone fusion material for patients and service providers - A Systematic Review. JBI Libr Syst Rev. 2010;8(8):1-13.
Darnley JE, Léger-St-Jean B, Pedroza AD, Flanigan DC, Kaeding CC, Magnussen RA. Anterior Cruciate Ligament Reconstruction Using a Combination of Autograft and Allograft Tendon: A MOON Cohort Study. Orthop J Sports Med. 2016;4(7):2325967116662249.
Mihara A, Muramatsu K, Hashimoto T, Iwanaga R, Ihara K, Sakai T. Combination of extracorporeally-irradiated autograft and vascularized bone graft for reconstruction of malignant musculoskeletal tumor. Anticancer Res. 2020;40(3):1637-43.
Winkler H, Haiden P. Allograft Bone as Antibiotic Carrier. J Bone Jt Infect. 2017;2(1):52-62
Coraça-Huber DC, Steixner SJM, Najman S, Stojanovic S, Finze R, Rimashevskiy D, Saginova D, Barbeck M, Schnettler R. Lyophilized Human Bone Allograft as an Antibiotic Carrier: An In Vitro and In Vivo Study. Antibiotics (Basel). 2022;11(7):969.
Elbers JBW, Leijtens B, van Werven HE, Sturm PD, Kullberg BJ, Schreurs BW. Antibiotic Mixing through Impacted Bone Grafts Does Not Seem Indicated in Two-Stage Cemented Hip Revisions for Septic Loosening. HIP Int. 2014;24(6):596-603.
Metsemakers WJ, Fragomen AT, Moriarty TF, Morgenstern M, Egol KA, Zalavras C et al. Evidence-Based Recommendations for Local Antimicrobial Strategies and Dead Space Management in Fracture-Related Infection. J Orthop Trauma. 2020;34(1):18-29.
Brown JL, Kumbar SG, Laurencin CT. Chapter II.6.7 - Bone Tissue Engineering. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JEBT-BS (Third E (eds). Academic Press. 2013;1194-214.
Donati D, Giacomini S, Gozzi E, Salphale Y, Mercuri M, Mankin HJ et al. Allograft arthrodesis treatment of bone tumors: a two-center study. Clin Orthop Relat Res. 2002;(400):217-24.
Lai WC, Bohlen HL, Fackler NP, Wang D. Osteochondral Allografts in Knee Surgery: Narrative Review of Evidence to Date. Orthop Res Rev. 2022;14:263-74.
Familiari F, Cinque ME, Chahla J, Godin JA, Olesen ML, Moatshe G et al. Clinical Outcomes and Failure Rates of Osteochondral Allograft Transplantation in the Knee: A Systematic Review. Am J Sports Med. 2018;46(14):3541-9.
Büyükdoğan K, Öztürkmen Y, Goker B, Melih O, Tolga A, Korhan Ö et al. Early results of a novel modular knee arthrodesis implant after uncontrolled periprosthetic knee joint infection. BMC Musculoskelet Disord. 2023;24:889.
Savvidou OD, Kaspiris A, Goumenos S, Trikoupis I, Melissaridou D, Kalogeropoulos A et al. Knee Arthrodesis with a Modular Silver-Coated Endoprosthesis for Infected Total Knee Arthroplasty with Extensive Bone Loss: A Retrospective Case-Series Study. J Clin Med. 2023;12(10):3600.