Serum levels of monocyte chemoattractant protein-1 has no correlation with gender and age in polytrauma


  • Mosimabale Balogun Department of Orthopaedic and Trauma, University College Hospital, Ibadan, Oyo State, Nigeria
  • Olubunmi Odeyemi 2College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
  • Olugboyega Oyewole Department of Orthopaedic and Trauma, University College Hospital, Ibadan, Oyo State, Nigeria
  • Tolulope Ogunrewo Department of Orthopaedic and Trauma, University College Hospital, Ibadan, Oyo State, Nigeria
  • Richard Omoyeni Department of Orthopaedic and Trauma, University College Hospital, Ibadan, Oyo State, Nigeria



MCP-1, Polytrauma, Inflammation, Chemo


Background: Trauma is one of the commonest causes of death among young people with significant increase in morbidity and mortality. Following injuries to tissues, the body responds in an attempt to cause repair of the damaged tissue. Although its significance depends on the interplay of various factors involving neurohormonal and immune responses. Monocyte chemoattractant protein-1 (MCP-1) is a pro-inflammatory chemoattractant produced by the monocyte and causes the further release of chemokines and cytokines needed at the site of tissue injury. It therefore plays a critical role in tissue healing.

Methods: This was a prospective hospital-based study carried out at University College Hospital (UCH), Ibadan. Polytrauma patients admitted through the accident and emergency department that met a defined criteria were recruited and had their blood samples taken into an endotoxin free test tube at 48±2 hours after trauma. MCP-1 levels in the serum were estimated though the human MCP-1 enzyme-linked immunosorbent assay (ELISA) kit. This process was carried out using the ELISA technique based on the producer’s guide.

Results: 110 patients were recruited for the study. There was no significant difference in gender variations in MCP-1 level (t=-0.935, p=0.351). For the male and female variations in MCP-1 levels, it ranges from 10 to 2841 and 22 to 2687 respectively. Likewise, there was no significant relationship in age variations in MCP-1 values (f=0.959, p>0.05).

Conclusions: This study demonstrated no correlation between serum level of monocyte chemoattractant protein-1 with age and gender in polytraumatized patient according to age and gender.

Author Biography

Mosimabale Balogun, Department of Orthopaedic and Trauma, University College Hospital, Ibadan, Oyo State, Nigeria

Department of Orthopaedic and Trauma, University College Hospital, Ibadan, Oyo State, Nigeria


Deshmane SL, Kremlev S, Amini S, Sawaya BE. Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res. 2009;29(6):313-26.

Wang X, Yue T-L, Barone FC, Feuerstein GZ. Monocyte Chemoattractant Protein–1 Messenger RNA Expression in Rat Ischemic Cortex. Stroke. 1995;26(4):661-6.

Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, et al. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor–deficient mice. Mol Cell. 1998;2(2):275-81.

Engelhardt E, Toksoy A, Goebeler M, Debus S, Bröcker E-B, Gillitzer R. Chemokines IL-8, GROα, MCP-1, IP-10, and Mig Are Sequentially and Differentially Expressed During Phase-Specific Infiltration of Leukocyte Subsets in Human Wound Healing. Am J Pathol. 1998;153(6):1849-60.

Wang Y, Liu Q, Liu T, Zheng Q, Gao W, Li Z, et al. Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients. Medicine (Baltimore). 2018;97(14):e0356.

Muhammad Q, Ukwuani SI. The Conundrum of Polytrauma in Sokoto, North-West Nigeria. J Trauma Treat. 2016;5(2).

Ozoilo KN, Nwadiaro HC, Iya D, Sule AZ. The Conundrum of Polytrauma on the Jos Plateau. West Afr J Med. 2012;31(1):6.

Krug EG, Sharma GK, Lozano R. The Global Burden of Injuries. Am J Public Health. 2000;90(4):4.

Elachi I, Yongu W, Odoyoh O-O, Mue D, Ogwuche E, Ahachi C. An epidemiological study of the burden of trauma in Makurdi, Nigeria. Int J Crit Illn Inj Sci. 2015;5(2):99.

Rollins BJ. Chemokines. Blood. J Am Soc Hematol. 1997;90(3):909-28.

Valković T, Dobrila F, Melato M, Sasso F, Rizzardi C, Jonjić N. Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma. Virchows Arch. 2002;440(6):583-8.

Catalán V, Frühbeck G, Gómez-Ambrosi J. Inflammatory and Oxidative Stress Markers in Skeletal Muscle of Obese Subjects. Obesity. 2018;163-89.

Ip WK, Wong CK, Lam CWK. Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways. Clin Exp Immunol. 2006;145(1):162-72.

Van Coillie E, Van Damme J, Opdenakker G. The MCP/eotaxin subfamily of CC chemokines. Cytokine & Growth Factor Reviews. 1999;10(1):61-86.

Ohta M, Kitadai Y, Tanaka S, Yoshihara M, Yasui W, Mukaida N, et al. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. Int J Oncol. 2003;22(4):773-8.

Nelken NA, Coughlin SR, Gordon D, Wilcox JN. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Investig. 1991;88(4):1121-7.

Frink M, Lu A, Thobe BM, Hsieh Y-C, Choudhry MA, Schwacha MG, et al. Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production. Am J Physiol Regul Integr Comp Physiol. 2007;292(3):R1110-6.

Rhodes JKJ, Sharkey J, Andrews PJD. The Temporal Expression, Cellular Localization, and Inhibition of the Chemokines MIP-2 and MCP-1 after Traumatic Brain Injury in the Rat. J Neurotrauma. 2009;26(4):507-25.

Yoshimura T. The production of monocyte chemoattractant protein-1 (MCP-1)/CCL2 in tumor microenvironments. Cytokine. 2017;98:71-8.

Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, Verity A, et al. Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. J Leukoc Biol. 1998;63(1):108-16.

Heydari-Khayat N, Sharifipoor H, Rezaei MA, Mohammadinia N, Darban F. Correlation of revised trauma score with mortality rate of traumatic patients within the first 24 hours of hospitalization. Zahedan J Res Med Sci. 2014;4:33-6.

Wick M, Ekkernkamp A, Muhr G. Epidemiologie des Polytraumas: Chirurg. 1997;68(11):1053-8.

Abhilash KP, Chakraborthy N, Pandian G, Dhanawade V, Bhanu T, Priya K. Profile of trauma patients in the emergency department of a tertiary care hospital in South India. J Family Med Prim Care. 2016;5(3):558.

Standiford TJ, Kunkel SL, Phan SH, Rollins BJ, Strieter RM. Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein-1 expression from human pulmonary type II-like epithelial cells. J Biol Chem. 1991;266(15):9912-8.

Im J-A, Kim S-H. Age-Associated Increasing of MCP-1 in Adults. Biomed Sci Lett. 2007;13(3):183-7.

Inadera H, Egashira K, Takemoto M, Ouchi Y, Matsushima K. Increase in circulating levels of monocyte chemoattractant protein-1 with aging. J Interferon Cytokine Res. 1999;19(10):1179-82.

Pervin S, Singh R, Rosenfeld ME, Navab M, Chaudhuri G, Nathan L. Estradiol Suppresses MCP-1 Expression In Vivo: Implications for Atherosclerosis. Arterioscler Thromb Vasc Biol. 1998;18(10):1575-82.

Im J-A, Kim S-H. Age-Associated Increasing of MCP-1 in Adults. Biomed Sci Lett. 2007;13(3):183-7

Cinque P, Vago L, Mengozzi M, Torri V, Ceresa D, Vicenzi E, et al. Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS. 1998;12(11):1327-32.

Banba N, Nakamura T, Matsumura M, Kuroda H, Hattori Y, Kasai K. Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Kidney Int. 2000;58(2):684-90.

Yamagami S, Tamura M, Hayashi M, Endo N, Tanabe H, Katsuura Y, et al. Differential production of MCP-1 and cytokine-induced neutrophil chemoattractant in the ischemic brain after transient focal ischemia in rats. J Leukoc Biol. 1999;65(6):744-9.

Rantapaa-Dahlqvist S, Boman K, Tarkowski A, Hallmans G. Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis. Ann Rheum Dis. 2006;66(1):121-3.

Sakurai-Yamashita Y, Shigematsu K, Yamashita K, Niwa M. Expression of MCP-1 in the Hippocampus of SHRSP with Ischemia-Related Delayed Neuronal Death. Cell Mol Neurobiol. 2006;26(4-6):821-9.






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