Evaluation of bone density and its relation with radiographic stage in knee osteoarthritis, 2016-2017

Authors

  • Hasan Anari Department of Radiology, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
  • Afsaneh Enteshari-Moghaddam Department of Internal Medicine, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
  • Farhad Pourfarzi Department of Community Medicine, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
  • Neda Safarzadeh School of Medicine, Ardabil University of Medical Science, Ardabil, Iran

DOI:

https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20221116

Keywords:

Osteoarthritis, T-score, Osteoporosis, Radiographic stage

Abstract

Background: Osteoarthritis (OA) is the most common arthritis and its incidence is directly related to age. According to the related research in the last 30 years, a relationship is reported between severity of osteoarthritis and bone density. The aim of this study was to investigate the bone density and its relation with radiographic stage in knee OA.

Methods: In this descriptive cross-sectional study, 123 patients with knee OA diagnosis who referred to rheumatology clinic at Imam Khomeini hospital in Ardabil, were selected to participate in our study. Age, sex, weight, height and other variables were collected and analyzed with SPSS version 21.

Results: A significant correlation was found between T-score and age of the patients (r=-0.38, p=0.001). A significant correlation was found between T-score and BMI. The correlation of T-score and radiographic stage of patients with osteoarthritis was indirect and non-significant (r=-0.22, p=0.06). Multivariate regression models showed that among variables, only two variables BMI and age had significant relation with T-score.

Conclusions: Results showed that the relation between radiographic stage and T-score was significant and BMI and age had a significant effect on T- score.

References

Brandt KD. Osteoarthritis. In: Braunwald K, Hauser F, Jameson L, eds. Harrisons principles of internal medicine. 19th ed. USA: Mc Graw-Hill Inc; 2015.

Hooper MM, Holderbaum D, Moskowitz RW. Clinical and laboratory findings in osteoarthritis. In: Man WJK, Moreland LW, eds. Arthritis and Allied Conditions. 15th ed. Philadelphia: Lippincott William and Wilkins; 2005.

Pelletier J, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease potential implication for the selection of new therapeutic targets. Arthritis Rheum. 2011;44(6):1237-47.

Enteshari-Moghaddam A, Isazadehfar K, Habibzadeh A, Hemmati M. Efficacy of methotrexate on pain severity reduction and improvement of quality of life in patients with moderate to severe knee osteoarthritis. Anesth Pain Med. 2019;9(3):89990.

Gupta KB, Duryea J, Weissman BN. Radiographic evaluation of osteoarthritis. Radiol Clin North Am. 2014;42(1):11-41.

Altman RD, Gold GE. Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthritis Cartilage. 2007;15:1-56.

Gold RM, Gregor TP, Huck JL, McKelvie PJ, Smith GK. Effects of osteoarthritis on radiographic measures of laxity and congruence in hip joints of Labrador Retrievers. J Am Vet Med Assoc. 2009;234(12):1549-54.

Kim C, Nevitt MC, Niu J, Clancy MM, Lane NE, Link TM, et al. Association of hip pain with radiographic evidence of hip osteoarthritis: diagnostic test study. BMJ. 2015;351(9):983.

Duncan RC, Hay EM, Saklatvala J, Croft PR. Prevalence of radiographic osteoarthritis-it all depends on your point of view. Rheumatology (Oxford). 2006;45(6):757-60.

Bedson J, Croft PR. The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskelet Disord. 2008;9(1):116.

Multanen J, Heinonen A, Häkkinen A, Kautiainen H, Kujala UM, Lammentausta E, et al. Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis. J Musculoskelet Neuronal Interact. 2015;15(1):69-77.

Wilson JL, Deluzio KJ, Dunbar MJ, Caldwell GE, Hubley-Kozey CL. The association between knee joint biomechanics and neuromuscular control and moderate knee osteoarthritis radiographic and pain severity. Osteoarthritis Cartilage. 2011;19(2):186-93.

Enteshari-Moghaddam A, Azami A, Isazadehfar K, Mohebbi H, Habibzadeh A, Jahanpanah P. Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis. Clin Rheumatol. 2019;38(10):2873-80.

Barr AJ, Dube B, Hensor EM, Kingsbury SR, Peat G, Bowes MA, et al. The relationship between clinical characteristics, radiographic osteoarthritis and 3D bone area: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2014;22(10):1703-9.

Silverwood V, Blagojevic-Bucknall M, Jinks C, Jordan JL, Protheroe J, Jordan KP. Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015;23(4):507-15.

Felson DT, Goggins J, Niu J, Zhang Y, Hunter DJ. The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum. 2004;50(12):3904-9.

Bennell KL, Hinman RS. A review of the clinical evidence for exercise in osteoarthritis of the hip and knee. J Sci Med Sport. 2011;14(1):4-9.

Mikesky AE, Mazzuca SA, Brandt KD, Perkins SM, Damush T, Lane KA. Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum. 2006;55(5):690-9.

Griffin TM, Guilak F. Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology. 2008;45(3-4):387-98.

Mounach A, Nouijai A, Ghozlani I, Ghazi M, Achemlal L, Bezza A, et al. Risk factors for knee osteoarthritis in Morocco. A case control study. Clin Rheumatol. 2008;27(3):323-6.

Teichtahl AJ, Wluka AE, Proietto J, Cicuttini FM. Obesity and the female sex, risk factors for knee osteoarthritis that may be attributable to systemic or local leptin biosynthesis and its cellular effects. Med Hypotheses. 2005;65(2):312-5.

Nevitt MC, Lane NE, Scott JC, Hochberg MC, Pressman AR, Genant HK, et al. The study of osteoporotic fractures research group. Radiographic osteoarthritis of the hip and bone mineral density. Arthritis Rheum. 1995;38(7):907-16.

Hochberg MC, Lethbridge-Cejku M, Tobin JD. Bone mineral density and osteoarthritis: data from the Baltimore longitudinal study of aging. Osteoarthritis Cartilage. 2004;12:45-8.

Živković V, Stamenković B, Nedović J, Dimić A, Marković K. Bone mineral density in osteoarthritis. Acta Facultatis Medicae Naissensis. 2010;27(3).

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Published

2022-04-25

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Original Research Articles