Single center, observational study to analyze correlation between vitamin D-3 deficiency and age in patients with orthopedic disorders

Authors

  • Girish Rathod Department of Orthopaedics, Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India
  • Nitin Raut Department of Orthopaedics, Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India
  • Pushkar Borole Department of Orthopaedics, Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India
  • Chandan Shetty Department of Orthopaedics, Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India
  • Vijaykumar Gawali Department of Medical Research at Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20214963

Keywords:

Prevalence, Vitamin-D deficiency, Orthopedic patients

Abstract

Background: Vitamin D deficiency has been strongly associated with various health outcomes, including all-cause mortality. Chronic vitamin D deficiency in adults and in old age results in osteomalacia, osteoporosis, muscle weakness, and increased risk of fall and long bone fractures. 

Methods: We examined records of 1029 such patients and to analyze association of vitamin d-3 levels and categories of age groups (1-20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80, 81-90 years). We categorized mild, moderate and severe cases age wise.

Results: During the study period records for 1029 patients were evaluated, of which 347 (33.72%) male and 682 (66.27) were female the mean age with standard deviation for male was 38.25±15.64 years and for female was 41.43±15.23 years. Vitamin D deficiency (<20 ng/ml) was present in 623 patients (61%), 189 patients (18%) had vitamin D level 20-30 ng/ml and 217 patients (21%) had sufficient levels of vitamin D.

Conclusions: Our study concludes that although there is high prevalence of vitamin D-3 deficiency across all age groups among orthopedic patients, age group 31-40 years, was found to be more affected.

 

Author Biographies

Girish Rathod, Department of Orthopaedics, Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India

Head of Orthopedic department, Consultant Orthopaedician
Bhaktivedanta Hospital And Research Institute Mira Road

Nitin Raut, Department of Orthopaedics, Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India

Consultant Orthopedics at Bhaktivedanta Hospital And Research Institute Mira Road, Mumbai.

Pushkar Borole, Department of Orthopaedics, Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India

Consultant Orthopedics at Bhaktivedanta Hospital And Research Institute Mira Road, Mumbai.

Chandan Shetty, Department of Orthopaedics, Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India

Consultant Orthopaedics at Bhaktivedanta Hospital & Research Institute Mira Road, Mumbai

Vijaykumar Gawali, Department of Medical Research at Bhaktivedanta Hospital and Research Institute Mira Road, Mumbai, Maharashtra, India

Head of Medical Research Department at Bhaktivedanta Hospital & Research Institute Mira Road, Mumbai

References

Holick M. The Vitamin D Deficiency Pandemic: A Forgotten Hormone Important for Health. Public Health Reviews. 2010;32(1):267-83.

Bordelon P, Ghetu MV, Langan RC. Recognition and management of vitamin D deficiency. Am Fam Physician. 2009 Oct 15;80(8):841-6. Erratum in: Am Fam Physician. 2009;80(12):1357.

Cashman K, Dowling K, Škrabáková Z, Gonzalez-Gross M, Valtueña J, De Henauw S et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutri. 2016;103(4):1033-44.

Cashman K. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing. Calcified Tissue Int. 2019;106(1):14-29.

Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Tmava Berisha A et al. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020;74(11):1498-513.

Pludowski P, Holick M, Pilz S, Wagner C, Hollis B, Grant W et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—A review of recent evidence. Autoimmunity Rev. 2013;12(10):976-89.

Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Molecular Biol. 2014;144:138-45.

Gallagher J. Vitamin D and Aging. Endocrinol Metabol Clin N Am. 2013;42(2):319-32.

Holick M. Vitamin D Status: Measurement, Interpretation, and Clinical Application. Ann Epidemiol. 2009;19(2):73-8.

Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M et al. Vitamin D deficiency and causative factors in the population of Tehran. BMC Public Health. 2004;4:1.

Pal C, Kumar H, Kumar D, Mittal V, Deshwar G, Altaf D et al. Prevalence of vitamin D deficiency in orthopaedic patients-A single centre study. J Clin Orthop Trauma. 2016;7:143-6.

Khadgawat R, Brar KS, Gahlot M, Yadav CS, Malhotra R, Gupta N et al. High prevalence of vitamin D deficiency in Asian-Indian patients with fragility hip fracture: a pilot study. J Asso Physicians India. 2010;58:539-42.

Kalra S, Kalra B, Khandelwal SK. Vitamin D status in patients with musculoskeletal symptoms in Haryana, India. J Med Nutr Nutraceut. 2012;1(1):50.

Hovsepian S, Amini M, Aminorroaya A, Amini P, Iraj B. Prevalence of vitamin D deficiency among adult population of Isfahan City, Iran. J Health Population Nutr. 2011;29(2):149.

MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Investig. 1985;76:1536-8.

Yetley EA. Assessing the vitamin D status of the US population. Am J Clin Nutr. 2008;88(2):558S-64S.

Bawaskar PH, Bawaskar HS, Bawaskar PH, Pakhare AP. Profile of Vitamin D in patients attending at general hospital Mahad India. Indian J Endocrinol Metab. 2017;21(1):125.

Downloads

Published

2021-12-24

Issue

Section

Original Research Articles