Translational science in chronic tendinopathies
DOI:
https://doi.org/10.18203/issn.2455-4510.IntJResOrthop20211636Keywords:
Tendinopathies, Translational sciences, TendonitisAbstract
Chronic tendinopathies involve majority of patients in clinical practice of orthopaedic surgeons and sports physicians. Translational medicine confers an emerging medical advance efficiently towards the clinician directly from scientists which may be used as a targeted therapy. The main objective of translational research from “bench to bedside” is to test novel inventions in humans. Our purpose in this article to understand the translational medicine approach for chronic tendinopathies in clinical aspects. Translational research in chronic tendinopathies is required certainly due to plenty of reasons. Newer advances and targeted approach to these tendon disorders may curtail the further degenerative process. It aids in earlier diagnosis and prevention of morbidity, early occupancy of occupational activity, lack of economical as well as recreational failure. Pre-disease level activity is ultimate goal of any therapy. Tendon pathophysiology is constantly evolving researched topic in both biochemical as well as molecular aspect. The basic fundamental understanding of complex process of tendon healing and regeneration is necessary for formulating a newer guideline. The cornerstone of treatment of tendinopathies is still non-operative management. Physical therapy, better pain control, NSAIDS are still primary choice for these conditions. Various biological therapy whenever used one should combined them with other appropriate options to obtain an optimum outcome.
References
Dijk VCN, van Sterkenburg VMN, Wiegerinck JI, Karlsson J, Maffulli N. Terminology for Achilles tendon related disorders. Knee Surg Sports Traumatol Arthrosc. 2011;19(5):835-41.
Alfredson H, Lorentzon R. Chronic tendon pain: no signs of chemical inflammation but high concentrations of the neurotransmitter glutamate.Implications for treatment? Curr Drug Targets. 2002;3(1):43-54.
Cook JL, Khan KM, Maffulli N, Purdam C. Overuse tendinosis, not tendinitis part 2: applying the new approach to patellar tendinopathy. Phys Sportsme. 2000;28(6):31-46.
Jordan KP, Jöud A, Bergknut C, Croft P, Edwards JJ, Peat G, Petersson IF, Turkiewicz A, Wilkie R, Englund M, International comparisons of the consultation prevalence of musculoskeletal conditions using population-based healthcare data from England and Sweden. Ann. Rheum. Dis. 2014;73:212-8.
5.Cook JL, Purdam CR Is tendon pathology a continuum? A pathology model to explain the clinical presentation of load-induced tendinopathy. Br. J. Sports Med. 2009;43:409-16.
6.Shearn JT, Kinneberg KR, Dyment NA, Galloway MT, Kenter K, Wylie C, et al. Tendon tissue engineering: Progress, challenges, and translation to the clinic. J. Musculoskelet. Neuronal Interact. 2011;11:163-73.
Astrom M, Rausing A. Chronic Achilles tendinopathy. A survey of surgical and histopathologic findings. Clin Orthop Relat Res. 1995;(316):151-64.
Schubert TEO, Weidler C, Lerch K, Hofstadter F, Straub RH. Achilles tendinosis is associated with sprouting of substance P positive nerve fibres. Ann Rheum Dis. 2005;64(7):1083-6.
Legerlotz K, Jones ER, Screen HRC, Riley GP.Increased expression of IL-6 family members in tendon pathology. Rheumatology (Oxford). 2012;51(7):1161-5.
Fenwick SA, Hazelman BL, Harrall R, Riley GP. Transforming growth factor-b isoform expression in chronic Achilles tendinopathy and their effects on tendon cell populations. Int J Exp Pathol. 2001;199(3):231-40.
Gotoh M, Hamada K, Yamakawa H, Inoue A, Fukuda H. Increased substance P in subacromial bursa and shoulder pain in rotator cuff diseases. J Orthop Res. 1998;16(5): 618-21.
Campbell AL, Smith NC, Reilly JH, Kerr SC, Leach WJ, Fazzi UG, et al. IL -21 receptor expression in human tendinopathy. Mediators Inflamm. 2014;2014: 481206.
Poulsen RC, Watts AC, Murphy RJ, Snelling SJ, Carr AJ, Hulley PA. Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence. Ann Rheum Dis 2014;73(7):1405-13.
Shakibaei M, Buhrmann C, Mobasheri A. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem 2011;286(13):11492-505.
Buhrmann C, Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, et al. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 2011;286(322):28556-66.
Hu JJ, Yin Z, Shen WL, Xie YB, Zhu T, Lu P, et al. Pharmacological regulation of in situ tissue stem cells differentiation for soft tissue calcification treatment. Stem Cells 2016;34(4): 1083-96.
Heisterbach PE, Todorov A, Fluckiger R, Evans CH, Majewski M. Effect of BMP-12, TGF-b1 and autologous conditioned serum on growth factor expression in Achilles tendon healing. Knee Surg Sports Traumatol Arthrosc 2012;20:1907-14.
Wurgler-Hauri CC, Dourte LM, Baradet TC, Williams GR, Soslowsky LJ, Thimoty BC. Temporal expression of 8 growth factors in tendon-to-bone healing in a rat supraspinatus model. J Shoulder Elbow Surg 2007;16:198-203.
Gosens T, Peerbooms JC, van Laar W, den Oudsten BL. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. Am J Sports Med 2011;39(6):1200-8.
Yan R, Gu Y, Ran J, Hu Y, Zheng Z, Zeng M, et al. Intratendon delivery of leukocyte-poor platelet-rich plasma improves healing compared with leukocyte-rich platelet-rich plasma in a rabbit achilles tendinopathy model. Am J Sports Med 2017;45(8):1909-20.
Ellera GJL, Da SRC, Silla LM, Abreu MR, Pellanda R. Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells. Knee Surg Sports Traumatol Arthrosc 2012;20(2):373-7.
Hernigou P, Flouzat LCH, Delambre J, Zilber S, Duffiet P, Chevallier N, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop 2014;38(9):1811-8.
Lee SY, Kim W, Lim C, Chung SG. Treatment of lateral epicondylosis by using allogeneic adipose-derived mesenchymal stem cells: a pilot study. Stem Cells 2015;33(10):2995-3005.
Shen W, Chen X, Chen J, Yin Z, Heng BC, Chen W, et al. The effect of incorporation of exogenous stromal cell-derived factor-1 alpha within a knitted silk-collagen sponge scaffold on tendon regeneration. Biomaterials 2010;31(28):7239-49.
Riley G. Tendinopathy–from basic science to treatment. Nat. Clin. Practice. Rheumatol. 2008;4(2):82-9.
Chimenti RL, Cychosz CC, Hall MM, Phisitkul P. Current Concepts Review Update: Insertional Achilles Tendinopathy. Foot Ankle Int. 2017;38:1160-9.
Chen JM, Willers C, Xu J, Wang A, Zheng MH. Autologous tenocyte therapy using porcine-derived bioscaffolds for massive rotator cu defect in rabbits. Tissue Eng. 2007;13:1479-91.
Kaux JF, Croisier JL, Forthomme B, Crielaard JM. Newconservative treatments of chronic tendinopathies. Revue Med Liege. 2015;70(10):507-10.
Ackermann PW, Renstrom P. Tendinopathy in sport. Sports health. 2012;4(3):193-201.
Koh JS, Mohan PC, Howe TS, Brain PL, Chia SL, Yang Z et al. Fasciotomy and surgical tenotomy for recalcitrant lateral elbow tendinopathy: early clinical experience with a novel device for minimally invasive percutaneous microresection. Am J Sports Med. 2013;41(3):636-44.
